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Titolo:
NEUROPATHOLOGY OF PRECLINICAL AND CLINICAL LATE-ONSET ALZHEIMERS-DISEASE
Autore:
TRONCOSO JC; CATALDO AM; NIXON RA; BARNETT JL; LEE MK; CHECLER F; FOWLER DR; SMIALEK JE; CRAIN B; MARTIN LJ; KAWAS CH;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,NEUROPATHOL LAB,720 RUTLAND AVE,558 ROSS BLDG BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,ALZHEIMERS DIS RES CTR BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI BALTIMORE MD 21205 MCLEAN HOSP,LAB MOL NEUROSCI BELMONT MA 02178 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BELMONT MA 02178 HARVARD UNIV,SCH MED,DEPT NEUROPATHOL BELMONT MA 02178 OFF CHIEF MED EXAMINER STATE MARYLAND BALTIMORE MD 00000 CNRS,INST PHARMACOL MOL & CELLULAIRE F-06560 VALBONNE FRANCE
Titolo Testata:
Annals of neurology
fascicolo: 5, volume: 43, anno: 1998,
pagine: 673 - 676
SICI:
0364-5134(1998)43:5<673:NOPACL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-BETA-PROTEIN; ENDOSOMAL-LYSOSOMAL SYSTEM; EXPRESSION; PATHWAY; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Troncoso et al., "NEUROPATHOLOGY OF PRECLINICAL AND CLINICAL LATE-ONSET ALZHEIMERS-DISEASE", Annals of neurology, 43(5), 1998, pp. 673-676

Abstract

We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal-lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:21:13