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Titolo:
IN-VIVO ROLES OF RECEPTOR TYROSINE KINASES AND CYTOKINE RECEPTORS IN EARLY THYMOCYTE DEVELOPMENT
Autore:
DISANTO JP; RODEWALD HR;
Indirizzi:
HOP NECKER ENFANTS MALAD,INSERM,U429,149 RUE SEVRES F-75743 PARIS FRANCE BASEL INST IMMUNOL CH-4005 BASEL SWITZERLAND
Titolo Testata:
Current opinion in immunology
fascicolo: 2, volume: 10, anno: 1998,
pagine: 196 - 207
SICI:
0952-7915(1998)10:2<196:IRORTK>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-KIT LIGAND; STEM-CELL FACTOR; NATURAL-KILLER-CELLS; COMMON GAMMA-CHAIN; DELTA T-CELLS; INTERLEUKIN-2 RECEPTOR; LYMPHOID DEVELOPMENT; MAST-CELLS; IN-VIVO; GENE REARRANGEMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
99
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Disanto e H.R. Rodewald, "IN-VIVO ROLES OF RECEPTOR TYROSINE KINASES AND CYTOKINE RECEPTORS IN EARLY THYMOCYTE DEVELOPMENT", Current opinion in immunology, 10(2), 1998, pp. 196-207

Abstract

The early phases of T-cell development require both cell-cell interactions and soluble factors provided by stromal cells within the thymic microenvironment. Still, the precise nature of the signals delivered in vivo by cytokines (resulting in survival, proliferation or differentiation) remains unclear. Recent studies using mice deficient in cytokines or in their receptors have helped to identify essential signaling pathways required for the development of intrathymic precursors to mature alpha beta and gamma delta T cells. In addition, cytokine requirements for the development of natural killer cells were revealed in suchmutants. The results obtained demonstrate that the development of allclasses of lymphocytes (natural killer, gamma delta T cells and alphabeta T cells) is cytokine dependent, but the specific requirements differ for each lineage. (C) Current Biology Ltd ISSN 0952-7915.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:44:36