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Titolo:
BCL-2 EXPRESSION AND PROGNOSIS OF PATIENTS WITH ENDOMETRIAL CARCINOMA
Autore:
SAKURAGI N; OHKOUCHI T; HAREYAMA H; IKEDA K; WATARI H; FUJIMOTO T; KUWABARA M; YAMAMOTO R; SAGAWA T; FUJINO T; FUJIMOTO S;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT OBSTET & GYNECOL SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
International journal of cancer
fascicolo: 2, volume: 79, anno: 1998,
pagine: 153 - 158
SICI:
0020-7136(1998)79:2<153:BEAPOP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; MENSTRUAL-CYCLE; DEPENDENT EXPRESSION; MEMBRANE PROTEIN; APOPTOSIS; P53; ADENOCARCINOMA; HYPERPLASIA; ONCOPROTEIN; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
N. Sakuragi et al., "BCL-2 EXPRESSION AND PROGNOSIS OF PATIENTS WITH ENDOMETRIAL CARCINOMA", International journal of cancer, 79(2), 1998, pp. 153-158

Abstract

Bcl-2 protein inhibits apoptosis, reduces the requirement for growth factors, and thereby extends the survival of cells. Recent findings ofBcl-2 in several solid tumors suggest that it might contribute to thegenesis of some types of cancer. Over-expression of Bcl-2 might play a role in carcinogenesis and malignant progression of endometrial carcinoma. The aims of this study were to determine Bcl-2 expression in endometrial carcinoma in relation to other histopathologic prognostic factors, and to test its prognostic significance in patients with endometrial carcinoma. A total of 61 endometrioid-type endometrial carcinomas were immunohistochemically investigated for Bcl-2 expression on cryostat sections. Bcl-2 localization was observed in cytoplasm in 18 tumors, in nucleus in 27 tumors, or in both in 5 tumors. In 11 tumors, Bcl-2 was observed neither in cytoplasm nor in nucleus. There was not a statistically significant relationship between grade of tumor and Bcl-2expression, Cytoplasmic Bcl-2 became less frequently expressed as thetumor invaded the myometrium deeper (P < 0.025), Retroperitoneal lymphnode dissection was performed in 57 patients. Multiple-regression analysis showed that lymph-vascular space invasion and nuclear expressionof Bcl-2 were correlated to pelvic lymph-node metastasis (p < 0.0001 and < 0.05 respectively). Univariate Cox regression analysis revealed that nuclear Bcl-2 expression was associated with shorter survival (p < 0.05) than that of patients with cytoplasmic Bcl-2 expression. Pelvic node metastasis was a significant prognostic factor for patients whounderwent systematic retroperitoneal lymph node dissection. Cox multivariate-regression analysis revealed that pelvic node metastasis and cervical invasion were the most important prognostic factors in this series of patients, When the analysis was made after exclusion of pelvicnode metastasis, histologic grade (hazard ratio = 2.4), cervical invasion (hazard ratio = 3.7) and nuclear Bcl-2 expression (hazard ratio =11.5) were shown to be significant predictors of survival of the patients. These results indicate that aberrant Bcl-2 expression might be involved in malignant progression of endometrioid-type endometrial carcinoma. Site of Bcl-2 localization may be an important predictor of prognosis for patients with endometrioid-type endometrial carcinoma. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:06:47