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Titolo:
BACTERIAL ADHESION PILI ARE HETEROLOGOUS ASSEMBLIES OF SIMILAR SUBUNITS
Autore:
BULLITT E; MAKOWSKI L;
Indirizzi:
BOSTON UNIV,SCH MED,DEPT BIOPHYS,715 ALBANY ST BOSTON MA 02118 FLORIDA STATE UNIV,INST MOL BIOPHYS TALLAHASSEE FL 32306
Titolo Testata:
Biophysical journal
fascicolo: 1, volume: 74, anno: 1998,
pagine: 623 - 632
SICI:
0006-3495(1998)74:1<623:BAPAHA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
UROPATHOGENIC ESCHERICHIA-COLI; F-ACTIN; FLEXIBILITY; PROTEIN; DNA; MICROSCOPY; COMPLEXES; RECEPTOR; LENGTH; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E. Bullitt e L. Makowski, "BACTERIAL ADHESION PILI ARE HETEROLOGOUS ASSEMBLIES OF SIMILAR SUBUNITS", Biophysical journal, 74(1), 1998, pp. 623-632

Abstract

P-pili on uropathogenic bacteria are 68-Angstrom-diameter rods typically 1 mu m in length. These structures project from the outer membraneof Escherichia coli, and contain on their distal tip a thin fibrillum, 25 Angstrom in diameter and 150 Angstrom, long, displaying an adhesin protein responsible for the binding of the bacterium to the surface of epithelial cells lining the urinary tract. Operationally, it is possible to identify three morphologically distinct states of the 68-Angstrom-diameter P-pili rods, based on the degree of curvature each can adopt. These states are designated ''straight,'' ''curved,'' and ''highly curved. '' The rods can also be unwound to form thin ''threads'' that are very similar to the tip fibrillae. Electron microscope data are used to distinguish among these four morphological states and to define limits on the shapes of the pilus proteins. The mechanical properties of the PapA polymers are assessed, and implications of rod polymorphism for pilus function are discussed. A wide variety of data are considered in light of the possibility that all pilins are similar in molecular architecture, with specific differences designed to optimize their specialized functions in the pilus assembly.

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Documento generato il 05/12/20 alle ore 09:55:53