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Titolo:
THE PROTECTIVE EFFECTS OF METABOLIC-RATE DEPRESSION IN HYPOXIC COLD SUBMERGED FROGS
Autore:
DONOHOE PH; BOUTILIER RG;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT ANESTHESIA,513 PARNASSUS AVE SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT NEUROL SAN FRANCISCO CA 94143 UNIV CAMBRIDGE,DEPT ZOOL CAMBRIDGE CB2 3EJ ENGLAND
Titolo Testata:
Respiration physiology
fascicolo: 3, volume: 111, anno: 1998,
pagine: 325 - 336
SICI:
0034-5687(1998)111:3<325:TPEOMD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; MUSCLE; ACID;
Keywords:
AMPHIBIANS, FROG; HIBERNATION, HYPOXIA, HYPOMETABOLISM; HYPOXIA, HYPOMETABOLISM; METABOLISM, HYPOXIA, HIBERNATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P.H. Donohoe e R.G. Boutilier, "THE PROTECTIVE EFFECTS OF METABOLIC-RATE DEPRESSION IN HYPOXIC COLD SUBMERGED FROGS", Respiration physiology, 111(3), 1998, pp. 325-336

Abstract

Aerobic metabolic rates ((M) over dot(O2)) and respiratory quotients (RQ = (M) over dot(CO2)/(M) over dot(O2)) were measured in hypoxic frogs, hibernating underwater for up to 90 days at 3 degrees C. After 3 months of submergence at a P-O2 of 50 mmHg. (M) over dot(O2) levels were 25% of those seen prior to hibernation. In progressive hypoxia, a gradual shift in RQ from 0.85 to 1.0 signaled an increasing reliance upon carbohydrate metabolism. Moreover, the glycogen concentrations of skeletal muscle, liver and heart of hypoxic frogs were more rapidly depleted than in their normoxic counterparts. A plasma lactacidosis revealed that the hypoxic animals recruited anaerobiosis to fuel a large 'Pasteur effect'. Throughout all stages of hypoxia, cellular ATP levels were maintained homeostatic. The ability to depress metabolic rate suchthat ATP demands can be met by oxidative phosphorylation in an oxygenlimited environment is the key to the frogs' overwintering survival. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:27:17