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Titolo:
MICROBIAL TRANSFORMATIONS OF HYPOLIPEMIC E-GUGGULSTERONE
Autore:
ATTAURRAHMAN; CHOUDHARY MI; SHAHEEN F; ASHRAF M; JAHAN S;
Indirizzi:
UNIV KARACHI,HEJ RES INST CHEM,INT CTR CHEM SCI KARACHI 75270 PAKISTAN
Titolo Testata:
Journal of natural products
fascicolo: 4, volume: 61, anno: 1998,
pagine: 428 - 431
SICI:
0163-3864(1998)61:4<428:MTOHE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
ATTAURRAHMAN et al., "MICROBIAL TRANSFORMATIONS OF HYPOLIPEMIC E-GUGGULSTERONE", Journal of natural products, 61(4), 1998, pp. 428-431

Abstract

Biotransformation of E-guggulsterone (pregna-4,17(20)-cis-diene-3,16-dione) (1) by Aspergillus niger resulted in the formation of four nearhydroxyl derivatives identified as 7 beta-hydroxypregna-4,17(20)-trans-diene-3,16-dione (2), 7 beta-hydroxypregna-4,17(20)-cis-diene-3,16-dione (3), 7 beta-hydroxypregn-4-ene-3,16-dione (4), and 7 beta,15 beta-dihydroxypregn-4-ene-3,16-dione (5). The biotransformation of 1 with Cephalosporium aphidicola also resulted in the formation of four new steroidal derivatives as 11 lpha-hydroxypregna-4,17(20)-trans-diene-3,16-dione (6), 11 alpha-hydroxypregna-4,17(20)-cis-diene-3,16-dione (7),11 alpha,15 ta-dihydroxypregna-4,17(20)-trans-diene-3,16-dione (8), and 11 alpha,15 beta-dihydroxypregna-4,17(20)-cis-diene-3,16-dione (9). The structures of these compounds were elucidated on the basis of 1D and 2D NMR spectroscopic techniques.

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Documento generato il 04/04/20 alle ore 02:55:53