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Titolo:
DNA-DAMAGE AND PREDICTION OF RADIATION RESPONSE IN LYMPHOCYTES AND EPIDERMAL SKIN HUMAN-CELLS
Autore:
NUNEZ MI; GUERRERO MR; LOPEZ E; DELMORAL MR; VALENZUELA MT; SILES E; VILLALOBOS M; PEDRAZA V; PEACOCK JH; DEALMODOVAR JMR;
Indirizzi:
UNIV GRANADA,DEPT RADIOL & MED FIS,LAB INVEST MED & BIOL TUMORAL,FAC MED E-18071 GRANADA SPAIN UNIV GRANADA,DEPT RADIOL & MED FIS,LAB INVEST MED & BIOL TUMORAL,FAC MED E-18071 GRANADA SPAIN HOSP VIRGEN NIEVES,SERV RADIOTERAPIA GRANADA SPAIN INST CANC RES,RADIOTHERAPY RES UNIT SUTTON SM2 5NG SURREY ENGLAND
Titolo Testata:
International journal of cancer
fascicolo: 3, volume: 76, anno: 1998,
pagine: 354 - 361
SICI:
0020-7136(1998)76:3<354:DAPORR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL-TISSUE RADIOSENSITIVITY; IN-VITRO RADIOSENSITIVITY; FIELD GEL-ELECTROPHORESIS; DOSE-RATE IRRADIATION; BREAST-CANCER; FIBROBLAST RADIOSENSITIVITY; INTRINSIC RADIOSENSITIVITY; CELLULAR RADIOSENSITIVITY; SUBCUTANEOUS FIBROSIS; MAMMALIAN-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Nunez et al., "DNA-DAMAGE AND PREDICTION OF RADIATION RESPONSE IN LYMPHOCYTES AND EPIDERMAL SKIN HUMAN-CELLS", International journal of cancer, 76(3), 1998, pp. 354-361

Abstract

The success of radiotherapy in eradicating tumours depends on the total radiation dose, but what limits this dose is the tolerance of the normal tissues within the treatment volume, Studies involving fibroblast survival have demonstrated the theoretical feasibility of a predictive assay of radiation sensitivity, but such an assay is still far fromclinical application. Using pulsed-field gel electrophoresis (PFGE), we have quantified the initial ''apparent'' number of DNA double-strand breaks (dsb) induced by the radiation as an alternative measure of sensitivity in 2 different normal cell types from the same patients, epidermal skin cells and lymphocytes. We found significant inter-individual variation in the measured dsb (1-5 dsb/Gy/DNA unit), We also founda linear correlation between molecular damage in lymphocytes and skinsamples from the same patient (slope = 0.83; r = 0.694; p = 0.0001). These results suggest that the initial number of dsb could be used as an indicator of the in vivo response to radiation. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:12:06