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Titolo:
INHIBITORY EFFECT OF DELPHINIDIN FROM SOLANUM-MELONGENA ON HUMAN FIBROSARCOMA HT-1080 INVASIVENESS IN-VITRO
Autore:
NAGASE H; SASAKI K; KITO H; HAGA A; SATO T;
Indirizzi:
GIFU PHARMACEUT UNIV,DEPT PUBL HLTH,5-6-1 MITAHORA HIGASHI GIFU 502 JAPAN
Titolo Testata:
Planta medica
fascicolo: 3, volume: 64, anno: 1998,
pagine: 216 - 219
SICI:
0032-0943(1998)64:3<216:IEODFS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVASION; CANCER; METASTASIS; CELLS; VEGETABLES; INVITRO; FRUIT;
Keywords:
DELPHINIDIN; SOLANUM MELONGENA; SOLANACEAE; INVASION; INHIBITION OF MATRIX METALLOPROTEINASE; HT-1080 CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Nagase et al., "INHIBITORY EFFECT OF DELPHINIDIN FROM SOLANUM-MELONGENA ON HUMAN FIBROSARCOMA HT-1080 INVASIVENESS IN-VITRO", Planta medica, 64(3), 1998, pp. 216-219

Abstract

We investigated the inhibitory effect of eggplant (Solanum melongena var, marunasu) extract on human fibrosarcoma HT-1080 cell invasion of reconstituted basement membrane [Matrigel (MG)]. We found that the effective component of the plant extract was delphinidin, a flavonoid pigment contained in the peel. The extract and delphinidin did not affecttumor cell adhesion to MG or haptotactic migration to MC. HT-1080 secretes matrix metalloproteinase(MMP)-2 and MMP-9, which degrade extracellular matrix as part of the invasive process. Delphinidin slightly inhibited the activity of MMPs, which may have been responsible, in part, for the inhibition of tumor cell invasiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:43:30