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Titolo:
SERUM LEVELS OF DIMERIC ACTIVIN A ARE NOT A MARKER OF PLACENTAL TUMORS IN THE COURSE OF CHEMOTHERAPY
Autore:
FLORIO P; LUISI S; CASAROSA E; GENAZZANI AR; PAUTIER P; LHOMME C; BIDART JM; DRIUL PG; PETRAGLIA F;
Indirizzi:
UNIV UDINE,DEPT SURG SCI,CHAIR OBSTET & GYNECOL,PIAZZA S MARIA MISERICODIA I-33100 UDINE ITALY UNIV PISA,DIPARTIMENTO OSTET & GINECOL PISA ITALY INST GUSTAVE ROUSSY,DEPT BIOL CLIN F-94805 VILLEJUIF FRANCE UNIV UDINE,DIPARTIMENTO CHIRURG,CATTEDRA OSTET & GINECOL I-33100 UDINE ITALY
Titolo Testata:
Journal of endocrinological investigation
fascicolo: 3, volume: 21, anno: 1998,
pagine: 166 - 169
SICI:
0391-4097(1998)21:3<166:SLODAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDATIDIFORM MOLE; PREGNANCY; INHIBIN; MEMBRANES;
Keywords:
ACTIVIN A; PLACENTAL TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
P. Florio et al., "SERUM LEVELS OF DIMERIC ACTIVIN A ARE NOT A MARKER OF PLACENTAL TUMORS IN THE COURSE OF CHEMOTHERAPY", Journal of endocrinological investigation, 21(3), 1998, pp. 166-169

Abstract

The aim of the present study was to evaluate whether serum activin A levels may represent, in addition to intact human chorionic gonadotrophin, a marker of placental tumors in the course of chemotherapy. Serial determinations of serum levels of activin A were performed in women with hydatidiform mole (n=2) or choriocarcinoma (n=3). Serum activin Alevels were measured by using a new specific two-site enzyme immunoassay (EIA) able to detect the dimeric, bioactive, form of the protein. Serum hCG concentrations in samples taken after evacuation before starting chemotherapy were greater than in healthy non-pregnant women (p<0.001) and decreased following chemotherapy. Activin A serum levels in women with trophoblastic disease after evacuation were significantly higher than in healthy nan-pregnant women, but chemotherapy did not significantly affect circulating levels. No correlation was found betweenchanges of activin A and total hCG serum concentrations. Measurement of activin A by ELISA in presence of persistent molar tumor does not seem to be of clinical interest in the follow-up of disease, resulting activin A concentrations after chemotherapy in the range of values occurring throughout menstrual cycle. These evidences suggest that hCG determination is still the most valid for follow-up, because only intacthCG could detect the persistence of trophoblast tissue. (C) 1998, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:17:55