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Titolo:
ULTRATHIN FILMS OF CHARGED POLYSACCHARIDES ASSEMBLED ALTERNATELY WITHLINEAR POLYIONS
Autore:
LVOV Y; ONDA M; ARIGA K; KUNITAKE T;
Indirizzi:
KYUSHU UNIV,FAC ENGN,6-10-1 HAKOZAKI FUKUOKA 812 JAPAN KURUME RES CTR,JST,SUPERMOL PROJECT KURUME FUKUOKA 839 JAPAN
Titolo Testata:
Journal of biomaterials science. Polymer ed.
fascicolo: 4, volume: 9, anno: 1998,
pagine: 345 - 355
SICI:
0920-5063(1998)9:4<345:UFOCPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUARTZ-CRYSTAL MICROBALANCE; ORAL SUSTAINED DELIVERY; WATER-SOLUBLE DRUGS; PHARMACEUTICAL INTERACTIONS; MULTILAYER FILMS; CHITOSAN BEADS; DOSAGE FORMS; ADSORPTION; RELEASE; POLYELECTROLYTES;
Keywords:
ALTERNATE LAYER-BY-LAYER ASSEMBLY; CHITOSAN; CHONDROITIN SULFATE; QUARTZ CRYSTAL MICROBALANCE; NONCONTACT ATOMIC FORCE MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
Y. Lvov et al., "ULTRATHIN FILMS OF CHARGED POLYSACCHARIDES ASSEMBLED ALTERNATELY WITHLINEAR POLYIONS", Journal of biomaterials science. Polymer ed., 9(4), 1998, pp. 345-355

Abstract

As a means of preparation of biocompatible molecular surfaces, an alternate assembly of charged polysaccharides and oppositely-charged synthetic polymers was conducted. Cationic chitosan was assembled alternately with anionic poly(sodium styrenesulfonate) (PSS) at pH 4. Regular film growth and its dependence on ionic strength were detected by the quartz crystal microbalance (QCM) method. Averaged film thicknesses for the chitosan + PSS layer were 15, 31, 46, and 69 Angstrom, respectively, when 0, 0.25, 0.5, and 1 M of NaCl was contained in aqueous chitosan. Adsorption of chitosan did not reach saturation in 20 min at 0 M NaCl, while the adsorption became saturated within 6 min with 0.25 M NaCl. Anionic sodium chondroitin sulfate was also assembled in alternation with cationic poly(dimethyldiallylammonium, chloride) (PDDA) at pH6.5. The adsorption of chondroitin sulfate was less sensitive to ionic strength. Surface morphology of chitosan-PSS films was investigated by non-contact atomic force microscopy (AFM) observation. Maximum height difference and Ra value for a 1000 x 1000 nm area were 11 and 0.69 nm, respectively, indicating the formation of a molecularly flat surface by alternate layer-by-layer adsorption.

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Documento generato il 27/09/20 alle ore 13:41:14