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Titolo:
BOVINE HERPESVIRUS-1 INFECTION AFFECTS THE PEPTIDE-TRANSPORT ACTIVITYIN BOVINE CELLS
Autore:
HINKLEY S; HILL AB; SRIKUMARAN S;
Indirizzi:
UNIV NEBRASKA,DEPT VET & BIOMED SCI LINCOLN NE 68583 UNIV NEBRASKA,DEPT VET & BIOMED SCI LINCOLN NE 68583 OREGON HLTH SCI UNIV,DEPT MOL MICROBIOL & IMMUNOL L220 PORTLAND OR 97201
Titolo Testata:
Virus research
fascicolo: 1, volume: 53, anno: 1998,
pagine: 91 - 96
SICI:
0168-1702(1998)53:1<91:BHIATP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; HIGHLY ONCOGENIC ADENOVIRUS-12; VIRAL-BACTERIAL PNEUMONIA; CLASS-I MOLECULES; DOWN-REGULATION; ANTIGEN PRESENTATION; HEAVY-CHAINS; VIRUS; PROTEIN; TAP;
Keywords:
BOVINE HERPESVIRUS 1; MHC CLASS I DOWN-REGULATION; TAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Hinkley et al., "BOVINE HERPESVIRUS-1 INFECTION AFFECTS THE PEPTIDE-TRANSPORT ACTIVITYIN BOVINE CELLS", Virus research, 53(1), 1998, pp. 91-96

Abstract

Infection of cattle with bovine herpesvirus-1 (BHV-1) impairs the cell-mediated immune response (CMI) of the affected host. We investigatedthe location of interference of BHV-1 with the major histocompatibility complex (MHC) class I antigen presentation pathway by employing an assay that allows assessment of the peptide transport activity of the Transporter associated with Antigen Presentation (TAP) from the cytoplasm into the endoplasmic reticulum (ER). We found a considerable down-regulation of the peptide transport activity in bovine epithelial cells, taking place as early as 2 h after virus infection. This down-regulation was also dose-dependent, and, at high multiplicities of infection (moi), led to an almost complete shutdown of TAP. By inhibiting peptide transport into the ER, the virus impairs loading of MHC class I molecules and their subsequent egress from the ER to the cell surface. This may lead to defective priming of cytotoxic T lymphocytes, Thus, BHV-1 is yet another member of its family Herpesviridae that selectivelyinterferes with the host's antigen presentation machinery to evade the host's immune response in vivo (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:37:10