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Titolo:
IN-VIVO DETECTION OF SHORT-TERM AND LONG-TERM MDMA NEUROTOXICITY - A POSITRON-EMISSION-TOMOGRAPHY STUDY IN THE LIVING BABOON BRAIN
Autore:
SCHEFFEL U; SZABO Z; MATHEWS WB; FINLEY PA; DANNALS RF; RAVERT HT; SZABO K; YUAN J; RICAURTE GA;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,220 ROSS RES BLDG,720 RUTLAND AVE BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT RADIOL,DIV NUCL MED BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT NEUROL BALTIMORE MD 21205
Titolo Testata:
Synapse
fascicolo: 2, volume: 29, anno: 1998,
pagine: 183 - 192
SICI:
0887-4476(1998)29:2<183:IDOSAL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN UPTAKE SITES; I-123 BETA-CIT; 5-HYDROXYTRYPTAMINE UPTAKE COMPLEX; RAT-BRAIN; IN-VIVO; NONHUMAN-PRIMATES; SELECTIVE LIGAND; MONOAMINE TRANSPORTERS; DOPAMINE TRANSPORTERS; COMPUTED-TOMOGRAPHY;
Keywords:
MDMA (3,4-METHYLENEDIOXYMETHAMPHETAMINE); SEROTONIN (5-HT); NEUROTOXICITY; PAPIO ANUBIS; PET (POSITRON EMISSION TOMOGRAPHY) IMAGING; [C-11] (+)MCN5652; [C-11] (-)MCN5652; [C-11] RTI-55 ([C-11]-BETA-CIT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
U. Scheffel et al., "IN-VIVO DETECTION OF SHORT-TERM AND LONG-TERM MDMA NEUROTOXICITY - A POSITRON-EMISSION-TOMOGRAPHY STUDY IN THE LIVING BABOON BRAIN", Synapse, 29(2), 1998, pp. 183-192

Abstract

The present study evaluated short-and long-term effects of MDMA (3,4-methylenedioxymethamphetamine) in the baboon brain using PET and [C-11](+)McN5652, a potent 5-HT transporter ligand, as well as [C-11]RTI-55, a cocaine derivative which labels both 5-HT and dopamine transporters. Following baseline PET scans with [C-11](+)McN5652, [C-11](-)McN5652 (the inactive enantiomer of the active enantiomer [C-11](+)McN5652) and [C-11]RTI-55, a baboon was treated with MDMA (5 mg/kg, s.c., twicedaily for four consecutive days). PET studies at 13, 19, and 40 days post-MDMA revealed decreases in mean radioactivity levels in all brainregions when using [C-11](+)McN5652, but not with [C-11](-)McN5652 or[C-11]RTI-55. Reductions in specific [C-11](+)McN5652 binding (calculated as the difference in radioactivity concentrations between (+) and(-)[C-11]McN5652) ranged from 44% in the pens to 89% in the occipitalcortex. PET studies at 9 and 13 months showed regional differences inthe apparent recovery of 5-HT transporters, with increases in some brain regions (e.g., hypothalamus) and persistent decreases in others (e.g., neocortex). Data obtained from PET studies correlated well with regional 5-HT axonal marker concentrations in the CNS measured after sacrifice of the animal. The results of these studies indicate that PET imaging of the living nonhuman primate brain with [C-11](+)McN5652 candetect changes in regional 5-HT transporter density secondary to MDMA-induced neurotoxicity. Using PET, it should also be feasible to use [C-11](+)McN5652 to determine whether human MDMA users are also susceptible to MDMA's neurotoxic effects. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 00:03:43