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Titolo:
ACTIVATING PROPERTIES OF COCAINE AND COCAETHYLENE IN A BEHAVIORAL PREPARATION OF DROSOPHILA-MELANOGASTER
Autore:
TORRES G; HOROWITZ JM;
Indirizzi:
SUNY BUFFALO,DEPT PSYCHOL,BEHAV NEUROSCI PROGRAM BUFFALO NY 14260
Titolo Testata:
Synapse
fascicolo: 2, volume: 29, anno: 1998,
pagine: 148 - 161
SICI:
0887-4476(1998)29:2<148:APOCAC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTORS; SEROTONIN TRANSPORTER; CONTAINING NEURONS; BRAIN; AMPHETAMINE; ETHANOL; SENSITIZATION; EXPRESSION; METABOLITE; ADDICTION;
Keywords:
BEHAVIOR; PSYCHOSTIMULANT DRUGS; DOPAMINE; GLUTAMATE; INVERTEBRATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
G. Torres e J.M. Horowitz, "ACTIVATING PROPERTIES OF COCAINE AND COCAETHYLENE IN A BEHAVIORAL PREPARATION OF DROSOPHILA-MELANOGASTER", Synapse, 29(2), 1998, pp. 148-161

Abstract

The use of Drosophila as a model to study the behavioral consequencesof stimulant drugs was analyzed in an active preparation of decapitated Drosophila. Application of cocaine and cocaethylene to discrete nerve cord cells regulating motor programs of behavior produced striking patterns of behavioral activity in a concentration-related manner. In general, intense circling behavior and significant wing buzzing activity were distinguishable behavioral markers in flies treated with mM. concentrations of cocaine or cocaethylene. The significant changes in motor behavior induced by stimulant drugs in decapitated flies were notreproduced by the application of apomorphine, a direct dopamine (DA) agonist, or octopamine, a naturally occurring transmitter in arthropods. Because both cocaine and cocaethylene interfere with DA reuptake inmammals, we characterized the role of DA receptors mediating increased stereotypy and motor behavior in flies. Coadministration of SCH-23390, a specific D-1 receptor antagonist, significantly attenuated the behavior-activating properties of cocaine and cocaethylene in this active experimental preparation. Therefore, the receptor protein mediating the behavioral responses to stimulant drugs in Drosophila is pharmacologically similar to the mammalian D-1 subtype. In rats, cocaine-and cocaethylene-induced behavioral activity is complex, with increasing evidence that the D-1 receptor interacts significantly with N-methyl-D-aspartate (NMDA) receptor pathways to produce an altered behavioral phenotype. To further characterize additional receptor subtypes targeted by the actions of cocaine and cocaethylene, we pretreated flies with MK-801 and dextromethorphan. Both of these drugs are potent, selective noncompetitive NMDA receptor antagonists. Interestingly, MK-801 and dextromethorphan profoundly reduced the behavior-activating properties ofcocaine and cocaethylene in Drosophila. Therefore, as in rats, the NMDA (and D-1) receptor pathways in this arthropod represent obligatory targets for the behavioral effects of stimulant drugs. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 04:17:14