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Titolo:
ACUTE AMMONIA TREATMENT IN-VITRO AND IN-VIVO INHIBITS THE SYNTHESIS OF A NEUROPROTECTANT KYNURENIC ACID IN RAT CEREBRAL CORTICAL SLICES
Autore:
SARAN T; HILGIER W; KOCKI T; URBANSKA EM; TURSKI WA; ALBRECHT J;
Indirizzi:
POLISH ACAD SCI,MED RES CTR,DEPT NEUROTOXICOL,PAWINSKIEGO 5 PL-02106 WARSAW POLAND POLISH ACAD SCI,MED RES CTR,DEPT NEUROTOXICOL PL-02106 WARSAW POLAND MARIE CURIE SKLODOWSKA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL PL-20090LUBLIN POLAND INST AGR MED,DEPT CLIN TOXICOL PL-20950 LUBLIN POLAND
Titolo Testata:
Brain research
fascicolo: 2, volume: 787, anno: 1998,
pagine: 348 - 350
SICI:
0006-8993(1998)787:2<348:AATIAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN; RECEPTORS;
Keywords:
RAT BRAIN; AMMONIA; HYPERAMMONEMIA; KYNURENIC ACID; EXCITOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
T. Saran et al., "ACUTE AMMONIA TREATMENT IN-VITRO AND IN-VIVO INHIBITS THE SYNTHESIS OF A NEUROPROTECTANT KYNURENIC ACID IN RAT CEREBRAL CORTICAL SLICES", Brain research, 787(2), 1998, pp. 348-350

Abstract

The synthesis of kynurenic acid (KYNA) from kynurenine was measured in the cerebral cortical slices. In vitro, ammonium acetate at the subtoxic to toxic concentration range from I mM to 10 mM dose-dependently inhibited KYNA synthesis (IC50 = 2.99 mM). Ammonia treatment in vivo decreased KYNA synthesis by 30%. These results suggest that impaired neuroprotection exerted by KYNA might be a potential contributor to the glutamate receptor-mediated aspect of acute ammonia neurotoxicity. (C)1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:32:32