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Titolo:
MUSCARINIC ACETYLCHOLINE-RECEPTOR SUBTYPES IN THE HUMAN IRIS
Autore:
ISHIZAKA N; NODA M; YOKOYAMA S; KAWASAKI K; YAMAMOTO M; HIGASHIDA H;
Indirizzi:
KANAZAWA UNIV,DEPT BIOPHYS,SCH MED,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920864 JAPAN KANAZAWA UNIV,DEPT BIOPHYS,SCH MED KANAZAWA ISHIKAWA 920864 JAPAN KANAZAWA UNIV,DEPT OPHTHALMOL,SCH MED KANAZAWA ISHIKAWA 920864 JAPAN KANAZAWA UNIV,DEPT ANAT,SCH MED KANAZAWA ISHIKAWA 920864 JAPAN
Titolo Testata:
Brain research
fascicolo: 2, volume: 787, anno: 1998,
pagine: 344 - 347
SICI:
0006-8993(1998)787:2<344:MASITH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPHINCTER SMOOTH-MUSCLE; PROTEINS; CELLS; ANTIBODIES;
Keywords:
MUSCARINIC ACETYLCHOLINE RECEPTOR; RECEPTOR SUBTYPE; HUMAN PUPIL; LIGHT REFLEX; IRIS SPHINCTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
N. Ishizaka et al., "MUSCARINIC ACETYLCHOLINE-RECEPTOR SUBTYPES IN THE HUMAN IRIS", Brain research, 787(2), 1998, pp. 344-347

Abstract

Employing subtype-specific antisera, we measured the relative immunoreactivity of five muscarinic acetylcholine receptor (mAChR) subtype proteins (m1-m5) in the human iris. The most intensive FITC immunofluorescence was detected by the anti-ms antibody, followed by anti-m1 and -m5 antisera, in the iris sphincter muscle cells. Only very weak fluorescence was obtained by anti-IL and -m4 antibodies. In dilator muscle cells, weak but not consistent immunoreactivity was found by anti-mi and -m5 antibodies. The results suggest that the m3 muscarinic receptor is the predominant subtype in sphincter muscle cells of the human iris. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:58:42