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Titolo:
EXPRESSION AND DISTRIBUTION OF CC CHEMOKINE MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA LD78 IN THE HUMAN BRAIN/
Autore:
ISHIZUKA K; IGATAYI R; KIMURA T; HIESHIMA K; KUKITA T; KIN Y; MISUMI Y; YAMAMOTO M; NOMIYAMA H; MIURA R; TAKAMATSU J; KATSURAGI S; MIYAKAWA T;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DEPT BIOCHEM,HONJO 2-2-1 KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DEPT BIOCHEM KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DEPT NEUROPSYCHIAT KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DEPT INTERNAL MED KUMAMOTO 860 JAPAN KYUSHU UNIV,FAC DENT,DEPT ORAL ANAT MAIDASHI FUKUOKA 812 JAPAN FUKUOKA UNIV,SCH MED,DEPT BIOCHEM FUKUOKA 81408 JAPAN FUKUOKA UNIV,SCH MED,DEPT NEUROSURG FUKUOKA 81408 JAPAN NATL KIKUCHI HOSP,DIV CLIN RES KUMAMOTO 86111 JAPAN
Titolo Testata:
NeuroReport
fascicolo: 5, volume: 8, anno: 1997,
pagine: 1215 - 1218
SICI:
0959-4965(1997)8:5<1215:EADOCC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; INFECTED MICE; CYTOKINE; CELLS; PROTEIN; FAMILY;
Keywords:
CHEMOKINES; GLIAL CELLS; LD78; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; MENTAL DISEASE; NEURONS; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K. Ishizuka et al., "EXPRESSION AND DISTRIBUTION OF CC CHEMOKINE MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA LD78 IN THE HUMAN BRAIN/", NeuroReport, 8(5), 1997, pp. 1215-1218

Abstract

MACROPHAGE inflammatory protein (MIP)-1 alpha, also known as LD78, isa member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1 alpha mRNA is expressed in several human tissues, including brain. To explore MIP-1 alpha distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1 alpha positive. Glial cells in the cortex from these patients were negative, exceptin one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1 alpha. In situ hybridization showed that MIP-1 alpha mRNA was expressed in both neurones as well as glial cells in this patient These results suggest a heterogeneous distribution of MIP-1 alpha in human brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:06:54