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Titolo:
PROGRESSIVE FOCAL NEUROLOGICAL DYSFUNCTION FOLLOWING EXPERIMENTAL IMPLANTATION GLIOMA
Autore:
WHITTLE IR; MARSTON HM;
Indirizzi:
UNIV EDINBURGH,WESTERN GEN HOSP,DEPT CLIN NEUROSCI EDINBURGH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT PHARMACOL,FUJISAWA INST NEUROSCI EDINBURGH MIDLOTHIAN SCOTLAND
Titolo Testata:
NeuroReport
fascicolo: 5, volume: 8, anno: 1997,
pagine: 1149 - 1153
SICI:
0959-4965(1997)8:5<1149:PFNDFE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKILLED FORELIMB USE; 6-HYDROXYDOPAMINE LESIONS; CORTICAL ABLATIONS; STRIATAL GRAFTS; CAUDATE-PUTAMEN; MOTOR ASYMMETRY; LIMB USE; RAT; DOPAMINE; BRAIN;
Keywords:
BRAIN DYSFUNCTION; GLIOMA; PAW-USE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
I.R. Whittle e H.M. Marston, "PROGRESSIVE FOCAL NEUROLOGICAL DYSFUNCTION FOLLOWING EXPERIMENTAL IMPLANTATION GLIOMA", NeuroReport, 8(5), 1997, pp. 1149-1153

Abstract

ONE of the difficulties in understanding peritumoural brain dysfunction is the lack of defined clinical deficits in experimental glioma models. In this study progressive focal neurological dysfunction was measured using the staircase test in rodents subjected to striatal implantation of C-6 glioma cells. After 22 days none of the animals, all of which had cortico-striatal tumours ranging in size from 93 to 140 mm(3), showed any obvious gross behavioural abnormality. However, contralateral forelimb function was significantly worse than that before surgery by day 7 (p < 0.01) and worse than shamimplanted animals by day 12 (p < 0.01). Using this experimental paradigm the staircase test can be used to measure progressive focal neurological deterioration and evaluate both the mechanisms of, and therapies for peritumoural brain dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:34:37