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Titolo:
EVOLUTION OF NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNITS
Autore:
TSUNOYAMA K; GOJOBORI T;
Indirizzi:
NATL INST GENET,CTR INFORMAT BIOL,YATA 111 MISHIMA SHIZUOKA 411 JAPAN NATL INST GENET,CTR INFORMAT BIOL MISHIMA SHIZUOKA 411 JAPAN GRAD UNIV ADV STUDIES,DEPT GENET MISHIMA SHIZUOKA JAPAN
Titolo Testata:
Molecular biology and evolution
fascicolo: 5, volume: 15, anno: 1998,
pagine: 518 - 527
SICI:
0737-4038(1998)15:5<518:EONAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GATED ION-CHANNEL; CENTRAL NERVOUS-SYSTEM; ALPHA-SUBUNIT; FUNCTIONAL EXPRESSION; GAMMA-SUBUNIT; EPSILON-SUBUNIT; NUCLEOTIDE-SEQUENCE; MOLECULAR-CLONING; CDNA SEQUENCE; BETA-SUBUNIT;
Keywords:
ACETYLCHOLINE RECEPTOR; EVOLUTION; FUNCTIONAL CONSTRAINTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
K. Tsunoyama e T. Gojobori, "EVOLUTION OF NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNITS", Molecular biology and evolution, 15(5), 1998, pp. 518-527

Abstract

A phylogenetic tree of a gene family of nicotinic acetylcholine receptor subunits was constructed using 84 nucleotide sequences of receptorsubunits from 18 different species in order to elucidate the evolutionary origin of receptor subunits. The tree constructed showed that thecommon ancestor of all subunits may have appeared first in the nervous system. Moreover, we suggest that the alpha(1) subunits in the muscle system originated from the common ancestor of alpha(2), alpha(3), alpha(4), alpha(5), alpha(6), and beta(3) in the nervous system, whereasthe beta(1), gamma, delta, and epsilon subunits in the muscle system shared a common ancestor with the beta(2) and beta(4) subunits in the nervous system. Using the ratio (f) of the number of nonsynonymous substitutions to that of synonymous substitutions, we predicted the functional importance of subunits. We found that the alpha(1) and alpha(7) subunits had the lowest f values in the muscle and nervous systems, respectively, indicating that very strong functional constraints work onthese subunits. This is consistent with the fact that the alpha(1) subunit has sites binding to the ligand, and the alpha(7)-containing receptor regulates the release of the transmitter. Moreover, the window analysis of the f values showed that strong functional constraints workon the so-called M2. region in all five types of muscle subunits. Thus, the window analysis of the f values is useful for evaluating the degree of functional constraints in not only the entire gene region, butalso the within-gene subregion.

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Documento generato il 02/04/20 alle ore 04:51:51