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Titolo:
CATEGORY-SPECIFIC SEMANTIC LOSS IN DEMENTIA OF ALZHEIMERS TYPE - FUNCTIONAL-ANATOMICAL CORRELATIONS FROM CROSS-SECTIONAL ANALYSES
Autore:
GARRARD P; PATTERSON K; WATSON PC; HODGES JR;
Indirizzi:
MRC,APPL PSYCHOL UNIT,15 CHAUCER RD CAMBRIDGE CB2 2QQ ENGLAND MRC,APPL PSYCHOL UNIT CAMBRIDGE CB2 2QQ ENGLAND UNIV CAMBRIDGE,ADDENBROOKES HOSP,NEUROL UNIT CAMBRIDGE CB2 2QQ ENGLAND
Titolo Testata:
Brain
, volume: 121, anno: 1998,
parte:, 4
pagine: 633 - 646
SICI:
0006-8950(1998)121:<633:CSLIDO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODALITY-SPECIFICITY; MEMORY IMPAIRMENT; NONLIVING THINGS; NAMING DEFICIT; DISEASE; KNOWLEDGE; DISSOCIATION; LANGUAGE; COMPREHENSION; ENCEPHALITIS;
Keywords:
CATEGORY SPECIFICITY; DEMENTIA OF ALZHEIMERS TYPE; SEMANTIC MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
P. Garrard et al., "CATEGORY-SPECIFIC SEMANTIC LOSS IN DEMENTIA OF ALZHEIMERS TYPE - FUNCTIONAL-ANATOMICAL CORRELATIONS FROM CROSS-SECTIONAL ANALYSES", Brain, 121, 1998, pp. 633-646

Abstract

In the context of focal brain injury, selective loss of semantic knowledge in the domain of either natural kinds or artefacts is usually considered to reflect the differential importance of temporal and frontoparietal regions to the representations of perceptual and functional attributes, respectively. It is harder to account for as a feature of amore diffuse process, and previous cross-sectional analyses of patients with dementia of Alzheimer's type (DAT) have differed over whether category effects occur. In our series of 58 patients with probable DAT, we demonstrated a significant group advantage for artefacts, and explored possible reasons for the inconsistency of this finding in other studies. A multiple single-case strategy revealed not only individualswith consistent advantages for artefacts but also individuals with consistent advantages for natural kinds. By ranking the individuals according to measures of naming performance and global intellectual ability we showed that the strength of the group advantage for artefacts wasdependent on the former brit not the latter variable. The findings are discussed in the context of two competing theories of semantic breakdown in DAT. One differentiates between domains of knowledge in terms of the structure of semantic representations within a single distributed network; the other emphasizes the importance of different brain regions in the category distinction. We conclude that our findings are inkeeping with the predictions of the latter hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:55:01