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Titolo:
INHIBITION OF IMMUNE CELL-PROLIFERATION WITH HALOPERIDOL AND RELATIONSHIP OF TYROSINE-HYDROXYLASE EXPRESSION TO IMMUNE CELL-GROWTH
Autore:
TSAO CW; LIN YS; CHENG JT;
Indirizzi:
NATL CHENG KUNG UNIV,COLL MED,DEPT PHARMACOL TAINAN 70101 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT PHARMACOL TAINAN 70101 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT MICROBIOL & IMMUNOL TAINAN 70101 TAIWAN
Titolo Testata:
Life sciences
fascicolo: 21, volume: 62, anno: 1998,
pagine: 335 - 344
SICI:
0024-3205(1998)62:21<335:IOICWH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOLAMINE BIOSYNTHESIS; DOPAMINE-RECEPTORS; HUMAN-LYMPHOCYTES; IDENTIFICATION; LEUKOCYTES; LINE;
Keywords:
TYROSINE HYDROXYLASE; CELL GROWTH; IMMUNE T CELLS; PC12 CELLS; ALPHA-METHYL-P-TYROSINE; 1-METHYL-4-PHENYL-1,2-3,6-TETRAHYDROPYRIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Tsao et al., "INHIBITION OF IMMUNE CELL-PROLIFERATION WITH HALOPERIDOL AND RELATIONSHIP OF TYROSINE-HYDROXYLASE EXPRESSION TO IMMUNE CELL-GROWTH", Life sciences, 62(21), 1998, pp. 335-344

Abstract

Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T cell hybridoma (10I) and rat nervous pheochromocytoma cells (PC12). Tyrosine hydroxylase (TH) catalyzes the initial rate-limiting step of catecholamine biosynthesis in the nervous system. Flow cytometric analysis indicated the expression of TH in various immune cells. The presence of TH in PC12 cells was used as a control. Temporal studies indicated that the expression of TH increased during 10I cell growth. Both alpha-methyl-p-tyrosine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine reduced TH expression and cell growth in a dose-dependent manner. These results suggest that immune T cells express TH which is correlated to cell growth, and that dopaminereleased from these cells may bind to the receptors to act in an autocrine or paracrine way. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:27:37