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Titolo:
A COMPARISON OF THE EFFECTS OF THE OPIOID ANTAGONISTS NALTREXONE, NALTRINDOLE, AND BETA-FUNALTREXAMINE ON ETHANOL-CONSUMPTION IN THE RAT
Autore:
STROMBERG MF; CASALE M; VOLPICELLI L; VOLPICELLI JR; OBRIEN CP;
Indirizzi:
UNIV PENN,CTR STUDIES ADDICT,3900 CHESTNUT ST PHILADELPHIA PA 19104
Titolo Testata:
Alcohol
fascicolo: 4, volume: 15, anno: 1998,
pagine: 281 - 289
SICI:
0741-8329(1998)15:4<281:ACOTEO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH ALCOHOL-DRINKING; SACCHARIN INTAKE; WATER-INTAKE; DELTA; PREFERENCE; NALOXONE; MORPHINE; RECEPTORS; OPIATE; SUPPRESSION;
Keywords:
OPIOID ANTAGONISTS; NALTREXONE; NALTRINDOLE; BETA-FUNALTREXAMINE; ETHANOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Stromberg et al., "A COMPARISON OF THE EFFECTS OF THE OPIOID ANTAGONISTS NALTREXONE, NALTRINDOLE, AND BETA-FUNALTREXAMINE ON ETHANOL-CONSUMPTION IN THE RAT", Alcohol, 15(4), 1998, pp. 281-289

Abstract

The effects of the universal opioid antagonist naltrexone were compared to the delta-selective opioid antagonist naltrindole and the mu-selective opioid antagonist beta-funaltrexamine on ethanol consumption inthe absence of food or fluid deprivation using a limited access procedure in Wistar rats. Both naltrexone, at doses of 0.1, 0.25, 0.5, 1.0,3.0, and 10 mg/kg, and beta-funaltrexamine, at doses of 5.0 and 20.0 mg/kg, significantly decreased consumption of a 6% ethanol solution compared to saline control groups. Naltrindole, at doses of 5.0 and 15.0mg/kg, failed to significantly reduce ethanol consumption. In addition, the highest doses of naltrexone, which antagonize delta as well as mu-opioid receptors, did not differ significantly from the lowest doses in their ability to reduce ethanol consumption. These data suggest that ethanol consumption using the limited access paradigm in the outbred rat is modulated by mu rather than delta-opioid receptors. Althoughthis is not consistent with other data showing that delta antagonistsdecrease ethanol consumption, it is suggested that these difference may be related to the alcohol-preferring rats used in those experiments. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:12:25