Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
APOLIPOPROTEIN-E GENOTYPE IN SPORADIC EARLY-ONSET AND LATE-ONSET ALZHEIMERS-DISEASE
Autore:
MASULLO C; DANIELE A; SERIPA D; FILIPPINI V; GRAVINA C; CARBONE G; GAINOTTI G; FAZIO VM;
Indirizzi:
UNIV SACRED HEART,UNIV HOSP A GEMELLI,NEUROL INST,LARGO A GEMELLI 8 I-00168 ROME ITALY IRCCS H CASA SOLLIEVO DELLA SOFFERENZA,LAB MOL PATHOL & GENE THERAPY SAN GIOVANNI ROTO ITALY ISRAELIT HOSP,SERV NEUROL ROME ITALY
Titolo Testata:
Dementia and geriatric cognitive disorders
fascicolo: 3, volume: 9, anno: 1998,
pagine: 121 - 125
Fonte:
ISI
Lingua:
ENG
Soggetto:
E EPSILON-2 ALLELE; LINKAGE DISEQUILIBRIUM; E POLYMORPHISM; INCREASED RISK; PROTEIN; CII;
Keywords:
APOLIPOPROTEIN E; ALZHEIMERS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C. Masullo et al., "APOLIPOPROTEIN-E GENOTYPE IN SPORADIC EARLY-ONSET AND LATE-ONSET ALZHEIMERS-DISEASE", Dementia and geriatric cognitive disorders, 9(3), 1998, pp. 121-125

Abstract

The epsilon 4 isoform of apolipoprotein E (ApoE) has been proposed asa risk factor for Alzheimer's disease (AD), while the possible role of the epsilon 2 allele in AD is controversial. We have studied the ApoE genotype in 38 patients with early-onset AD (EOAD) and in 43 patients with late-onset AD (LOAD). In the LOAD group we observed a significant increase of epsilon 4 allele frequency as compared with normal controls, while there was a more than 3-fold decrease of epsilon 2 allele frequency that did not reach statistical significance. In the LOAD group we found a highly significant increase of epsilon 4 allele frequency as compared with normal controls, while there was a significant decrease of epsilon 2 allele frequency. In both the EOAD and LOAD groups, no significant difference was observed between epsilon 4 carriers and epsilon 4 noncarriers as for age at disease onset, disease duration, and Mini-Mental State score at observation. However, in both EOAD and LOAD groups a statistical trend towards a longer disease duration was observed in epsilon 4 carriers. In both the EOAD and LOAD groups, disease severity was compared in epsilon 4 carriers versus epsilon 4 noncarriers by means of analyses of covariance, with disease duration as covariate. No significant difference between epsilon 4 carriers and epsilon 4 noncarriers was observed in both EOAD and LOAD. The results of the present study confirm that epsilon 4 allele seems to be associated with an increased risk for sporadic AD, while the significant decrease of epsilon 2 allele frequency in the LOAD group supports the hypothesis of a possible protective role of epsilon 2 allele in AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:46:39