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Titolo:
POSITIVE INOTROPIC EFFECTS OF THE NOVEL NA-CHANNEL MODULATOR BDF-9198IN HUMAN NONFAILING AND FAILING MYOCARDIUM()
Autore:
MULLEREHMSEN J; BRIXIUS K; SCHWINGER RHG;
Indirizzi:
UNIV COLOGNE,INNERE MED KLIN 3,LAB MUSCLE RES & MOL CARDIOL,JOSEPH STELZMANN STR 9 D-50924 COLOGNE GERMANY UNIV COLOGNE,INNERE MED KLIN 3,LAB MUSCLE RES & MOL CARDIOL D-50924 COLOGNE GERMANY
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 5, volume: 31, anno: 1998,
pagine: 684 - 689
SICI:
0160-2446(1998)31:5<684:PIEOTN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE HEART-FAILURE; HUMAN VENTRICULAR MYOCARDIUM; DILATED CARDIOMYOPATHY; CARDIAC PREPARATIONS; CALCIUM SENSITIVITY; BETA-ADRENOCEPTORS; NA+-CA2+ EXCHANGER; PAPILLARY-MUSCLES; ATRIAL MYOCARDIUM; ISOMETRIC TENSION;
Keywords:
HUMAN MYOCARDIUM; HEART FAILURE; POSITIVE INOTROPIC AGENTS; NA+-CHANNEL MODULATORS; BDF 9198; BDF 9148;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J. Mullerehmsen et al., "POSITIVE INOTROPIC EFFECTS OF THE NOVEL NA-CHANNEL MODULATOR BDF-9198IN HUMAN NONFAILING AND FAILING MYOCARDIUM()", Journal of cardiovascular pharmacology, 31(5), 1998, pp. 684-689

Abstract

The aim of this study was to investigate the inotropic properties of the novel Na+-channel modulator BDF: 9198 in human nonfailing and failing myocardium, For comparison the Na+-channel modulator BDF 9148, thebeta-adrenoceptor-agonist isoprenaline, and calcium were studied. Concentration-response curves for BDF 9198 (0.01-30 mu M), BDF 9148 (0.01-30 mu M), isoprenaline (0.001-1 mu M), and calcium (1.8-15 mM) were obtained in electrically driven left ventricular human papillary musclestrips (1 Hz, 37 degrees C; dilated cardiomyopathy, NYHA IV, heart transplantation; nonfailing, donor hearts). Whereas isoprenaline was significantly less effective and less patent in increasing the farce of contraction in failing human myocardium than in nonfailing myocardium (p < 0.01), BDF 9198 and BDF 9148 were tin NYHA IV) as effective as in nonfailing:: human tissue. In both tissues, BDF 9198 and BDF 9148 exerted similar positive inotropic effects as calcium, with the novel Na+-channel modulator BDF9198 being more potent in increasing force of contraction than was the preceding agent BDF 9148. The potencies of both Na+-channel modulators, BDF 9198 and BDF 9148, were enhanced in human failing myocardium when compared with nonfailing myocardium. In summary, the novel Na+-channel modulator BDF 9198 increases force of contraction to the same extent as calcium and with a higher potency than BDF 9148. The sensitivity of failing human myocardium to Na+-channel modulators is increased when compared with nonfailing myocardium, which might be the result of an altered Na+ homeostasis in human heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:45:10