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Titolo:
CHLORMETHIAZOLE ANTICONVULSIVE EFFICACY DIMINISHED BY N-METHYL-D-ASPARTATE BUT NOT KAINATE IN MICE
Autore:
PILIP S; URBANSKA EM; CZUCZWAR SJ; KLEINROK Z; TURSKI WA;
Indirizzi:
MARIE CURIE SKLODOWSKA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND MARIE CURIE SKLODOWSKA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL PL-20090LUBLIN POLAND INST AGR MED,DEPT CLIN TOXICOL PL-20950 LUBLIN POLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 345, anno: 1998,
pagine: 257 - 260
SICI:
0014-2999(1998)345:3<257:CAEDBN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID ANTAGONISTS; NMDA; SEIZURES; RAT; ANTIEPILEPTICS; EPILEPSY; COMPLEX; BRAIN;
Keywords:
CHLORMETHIAZOLE; ANTICONVULSANT; NMDA (N-METHYL-D-ASPARTATE); KAINATE; SEIZURE; (MOUSE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
S. Pilip et al., "CHLORMETHIAZOLE ANTICONVULSIVE EFFICACY DIMINISHED BY N-METHYL-D-ASPARTATE BUT NOT KAINATE IN MICE", European journal of pharmacology, 345(3), 1998, pp. 257-260

Abstract

The aim of this study was to evaluate the effect of N-methyl-D-aspartate (NMDA) and kainate used at nonconvulsive doses upon protective efficacy of chlormethiazole against maximal electroshock-induced seizures. NMDA (50 mg/kg, i.p.) reduced the anticonvulsant potency of chlormethiazole increasing its ED50 value from 126.9 to 155.0 mg/kg. The effect of NMDA was completely reversed by the competitive NMDA receptor antagonist D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 40116) (0.06 mg/kg i.p.), Kainic acid (9 mg/kg i.p.) did not affect the anticonvulsive properties of chlormethiazole. Our results suggest that NMDA but not kainate receptor-mediated events participate in the anticonvulsant action of chlormethiazole. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:07:31