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Titolo:
PTEN MUTATIONS IN GLIOMAS AND GLIONEURONAL TUMORS
Autore:
DUERR EM; ROLLBROCKER B; HAYASHI Y; PETERS N; MEYERPUTTLITZ B; LOUIS DN; SCHRAMM J; WIESTLER OD; PARSONS R; ENG C; VONDEIMLING A;
Indirizzi:
UNIV KLINIKEN BONN,INST NEUROPATHOL,SIGMUND FREUD STR 25 D-53105 BONNGERMANY UNIV BONN,CTR MED,DEPT NEUROPATHOL D-53105 BONN GERMANY MASSACHUSETTS GEN HOSP,CS KUBIK LAB NEUROPATHOL BOSTON MA 02114 MASSACHUSETTS GEN HOSP,MOL NEUROONCOL LAB BOSTON MA 02114 HARVARD UNIV,SCH MED BOSTON MA 02114 UNIV BONN,MED CTR,DEPT NEUROSURG D-53105 BONN GERMANY COLUMBIA UNIV COLL PHYS & SURG,DEPT PATHOL NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT MED NEW YORK NY 10032 HARVARD UNIV,SCH MED,DANA FARBER CANC INST BOSTON MA 02115
Titolo Testata:
Oncogene
fascicolo: 17, volume: 16, anno: 1998,
pagine: 2259 - 2264
SICI:
0950-9232(1998)16:17<2259:PMIGAG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LHERMITTE-DUCLOS DISEASE; HUMAN GLIOBLASTOMA-MULTIFORME; MOLECULAR-GENETIC-ANALYSIS; COWDEN SYNDROME; P53 MUTATIONS; CHROMOSOME-10; HETEROZYGOSITY; AMPLIFICATION; ASTROCYTOMA; LOCI;
Keywords:
PTEN MUTATIONS; GLIOBLASTOMA; OLIGODENDROGLIOMA; GANGLIOGLIOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Duerr et al., "PTEN MUTATIONS IN GLIOMAS AND GLIONEURONAL TUMORS", Oncogene, 16(17), 1998, pp. 2259-2264

Abstract

Cytogenetic and loss of heterozygosity studies have suggested the presence of at least one tumor suppressor gene on chromosome 10 involved in the formation of high grade gliomas, Recently, the PTEN gene, also termed MMAC1 or TEP1, on chromosomal band 10q23 has been identified. Initial studies revealed mutations of PTEN in limited series of glioma cell lines and glioblastomas. In order to systematically evaluate the involvement of PTEN in gliomas, we have analysed the entire PTEN coding sequence by SSCP and direct sequencing in a series of 331 gliomas and glioneuronal tumors. PTEN mutations mere detected in 20/142 glioblastomas, 1/7 giant cell glioblastomas, 1/2 gliosarcomas, 1/30 pilocytic astrocytomas and 2/22 oligodendrogliomas, No PTEN mutations were detected in 52 astrocytomas, 37 oligoastrocytomas, three subependymal giantcell astrocytomas, four pleomorphic xanthoastrocytomas, 15 ependymomas, 16 gangliogliomas and one dysembryoplastic neuroepithelial tumor. In addition, all tumors were examined for the presence of homozygous deletions of the PTEN gene; these were detected in 7 glioblastomas that did not have PTEN mutations. Therefore, PTEN mutations occur in approximately 20% of glioblastomas but are rare in lower grade gliomas, These findings confirm that PTEN is one of the chromosome 10 tumor suppressor genes involved in the development of glioblastomas.

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Documento generato il 02/12/20 alle ore 14:52:15