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Titolo:
TESTING CAUSAL HYPOTHESES IN MULTIVARIATE LINKAGE ANALYSIS OF QUANTITATIVE TRAITS - GENERAL FORMULATION AND APPLICATION TO SIBPAIR DATA
Autore:
TODOROV AA; VOGLER GP; GU C; PROVINCE MA; LI Z; HEATH AC; RAO DC;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,40N KINGSHIGHWAY ST LOUIS MO 63108 PENN STATE UNIV,CTR SPECIAL POPULAT & HLTH UNIVERSITY PK PA 16802 LOYOLA UNIV,MED CTR,DEPT EPIDEMIOL & PREVENT MED CHICAGO IL 60611 WASHINGTON UNIV,SCH MED,DIV BIOSTAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
Genetic epidemiology
fascicolo: 3, volume: 15, anno: 1998,
pagine: 263 - 278
SICI:
0741-0395(1998)15:3<263:TCHIML>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASSESSING GENETIC-LINKAGE; DISCORDANT SIB PAIRS; PEDIGREE ANALYSIS; VARIANCE-COMPONENTS; COMBINED SEGREGATION; FAMILY RESEMBLANCE; REGRESSIVE MODELS; PATH-ANALYSIS; LOCI; EXTENSIONS;
Keywords:
QUANTITATIVE TRAIT LINKAGE; EPISTASIS; STRUCTURAL RELATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Todorov et al., "TESTING CAUSAL HYPOTHESES IN MULTIVARIATE LINKAGE ANALYSIS OF QUANTITATIVE TRAITS - GENERAL FORMULATION AND APPLICATION TO SIBPAIR DATA", Genetic epidemiology, 15(3), 1998, pp. 263-278

Abstract

We provide a general framework for the development of model-free methods for the linkage analysis of multivariate phenotypic data. It is possible within this framework to test both for linkage of a set of phenotypes to one or more markers and for the presence of structural relations among the phenotypes themselves. This report presents the generalmodel, paying special attention to the assumptions that enter its formulation, and outlines the estimation procedures that may be used. (C)1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:40:33