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Titolo:
CODON-972 POLYMORPHISM OF THE INSULIN-RECEPTOR SUBSTRATE-1 GENE IN IMPAIRED GLUCOSE-TOLERANCE AND LATE-ONSET NIDDM
Autore:
YAMADA K; YUAN XH; ISHIYAMA S; SHOJI S; KOHNO S; KOYAMA K; KOYANAGI A; KOYAMA W; NONAKA K;
Indirizzi:
KURUME UNIV,SCH MED,DEPT MED,DIV ENDOCRINOL & METAB,67 ASAHIMACHI KURUME FUKUOKA 830 JAPAN KUMAMOTO RED CROSS HLTH CARE CTR KUMAMOTO JAPAN
Titolo Testata:
Diabetes care
fascicolo: 5, volume: 21, anno: 1998,
pagine: 753 - 756
SICI:
0149-5992(1998)21:5<753:CPOTIS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; AMINO-ACID POLYMORPHISMS; VARIANT SEQUENCES; JAPANESE SUBJECTS; RESISTANCE; PROTEIN; OBESITY; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K. Yamada et al., "CODON-972 POLYMORPHISM OF THE INSULIN-RECEPTOR SUBSTRATE-1 GENE IN IMPAIRED GLUCOSE-TOLERANCE AND LATE-ONSET NIDDM", Diabetes care, 21(5), 1998, pp. 753-756

Abstract

OBJECTIVE - To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM. RESEARCH DESIGN AND METHODS - The genotype of 1,106 Japanese subjects consisting of 310 subjects with NIDDM, 305 subjects with IGT, and 491 normal control subjects was analyzed by an allele-specific assay using polymerase chain reaction and restriction fragment length polymorphism. RESULTS - The frequency of the variant allele was not different between subjects with NIDDM (0.021) and normal control subjects (0.020). However, subjects with IGT showed a significantly higher prevalence of the variant allele (0.041, P = 0.027). We found two homozygous individuals for the variant; both had IGT with mild insulin resistance. The allelic frequency tended to be lower in normal control subjects aged >50 years than in younger control subjects. Conversely, in the subjects with IGT or NIDDM, the Gly972Arg substitution was more frequently found in subjects aged >50 years. Furthermore, NIDDM patients with the variant allele had older ages of diagnosis than patients without the variant.CONCLUSIONS - The codon 972 variant maybe associated with IGT and a subset of late-onset NIDDM in the elderly Japanese population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:50:05