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Titolo:
IBZM-SPECT IMAGING OF DOPAMINE D-2 RECEPTORS WITH TYPICAL AND ATYPICAL ANTIPSYCHOTICS
Autore:
KASPER S; TAUSCHER J; KUFFERLE B; HESSELMANN B; BARNAS C; BRUCKE T;
Indirizzi:
UNIV VIENNA,DEPT GEN PSYCHIAT,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT GEN NEUROL VIENNA AUSTRIA
Titolo Testata:
European psychiatry
, volume: 13, anno: 1998, supplemento:, 1
pagine: 9 - 14
SICI:
0924-9338(1998)13:<9:IIODDR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON-EMISSION TOMOGRAPHY; SCHIZOPHRENIC-PATIENTS; NEUROLEPTICS; CLOZAPINE; BLOCKADE; BINDING; HALOPERIDOL; OCCUPANCY; HUMANS; DRUG;
Keywords:
ANTIPSYCHOTICS; SCHIZOPHRENIA DOPAMINE; RECEPTORS; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S. Kasper et al., "IBZM-SPECT IMAGING OF DOPAMINE D-2 RECEPTORS WITH TYPICAL AND ATYPICAL ANTIPSYCHOTICS", European psychiatry, 13, 1998, pp. 9-14

Abstract

Considerable progress has been achieved over the past 15 years in uncovering the biological basis of major psychiatric disorders. Since psychopharmacological treatment is thought to act on the underlying biological basis of the disease, brain imaging techniques enable us to understand the mechanism of action of such compounds. One important tool used to determine patterns of brain dysfunction and how psychopharmacological agents such as antipsychotic compounds work is single-photon emission computerised tomography (SPECT). This technique allows determination of striatal D-2 receptor occupancy rates, which are associated with the extrapyramidal side effects (EPS) of antipsychotic drugs. Studies have confirmed that atypical antipsychotic agents have lower occupancy rates than typical agents. No association has been found between D-2 receptor occupancy rates in the striatum and antipsychotic efficacy, and it therefore appears that striatal D-2 receptor occupancy ratesare not necessary for the antipsychotic effect of such agents in schizophrenia. The availability of more refined radioligands will help us not only to understand the action of antipsychotics but also the pathophysiology of schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:28:27