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Titolo:
A NESTED CASE-CONTROL STUDY OF DIETARY FACTORS AND THE RISK OF INCIDENT CYTOLOGICAL ABNORMALITIES OF THE CERVIX
Autore:
WIDEROFF L; POTISCHMAN N; GLASS AG; GREER CE; MANOS MM; SCOTT DR; BURK RD; SHERMAN ME; WACHOLDER S; SCHIFFMAN M;
Indirizzi:
NCI,DCCPS,ARB,EPN 313,MSC 7344,6130 EXECUT BL BETHESDA MD 20892 NCI,EPIDEMIOL & BIOSTAT PROGRAM,DIV CANC EPIDEMIOL & GENET BETHESDA MD 20892 KAISER PERMANENTE CTR HLTH RES PORTLAND OR 97227 CHIRON CORP EMERYVILLE CA 94608 KAISER RES INST OAKLAND CA 94611 YESHIVA UNIV ALBERT EINSTEIN COLL MED BRONX NY 10461 JOHNS HOPKINS MED INST,DEPT PATHOL BALTIMORE MD 21205
Titolo Testata:
Nutrition and cancer
fascicolo: 2, volume: 30, anno: 1998,
pagine: 130 - 136
SICI:
0163-5581(1998)30:2<130:ANCSOD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAEPITHELIAL NEOPLASIA; VITAMIN-A; CANCER; FOLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
L. Wideroff et al., "A NESTED CASE-CONTROL STUDY OF DIETARY FACTORS AND THE RISK OF INCIDENT CYTOLOGICAL ABNORMALITIES OF THE CERVIX", Nutrition and cancer, 30(2), 1998, pp. 130-136

Abstract

Several earlier case-control studies reported inverse associations ofcervical squamous intraepithelial lesions (SIL) with high dietary or biomarker levels of carotenoids, folate, and vitamins C and E. However, most studies did not measure the primary causal factor, cancer-associated genital human papillomaviruses (HPV), now detected by sensitive viral DNA tests. This nested case-control study assessed whether high dietary intakes of these nutrients, plus zinc and vitamin A, reduced SIL risk in cancer-associated HPV DNA-positive women. Using a 60-item food-frequency questionnaire, nutrient estimates were obtained for 33 incident cases with high-grade lesions, 121 with low-grade lesions, 97 with equivocal SIL, and 806 cytologically normal controls sampled froma large prospective cohort study. Baseline cervicovaginal lavages were tested for HPV DNA by the polymerase chain reaction. Among DNA-positive cases (n = 68) and controls (n = 69), age-adjusted odds ratios (ORs) of SIL in the highest vs, the lowest nutrient quartiles were 1.4 [95% confidence interval (CI) = 0.5-4.2] for vitamin A, 0.6 (CI = 0.2-2.0) for beta-carotene, 1.3 (CI = 0.4-3.6) for vitamin C, 1.0 (CI = 0.4-3.6) for vitamin E, 0.7 (CI = 0.3-2.1) for folate, and 0.8 (CI = 0.3-2.2) for zinc. ORs in HPV DNA-negative women approximated 1.0, with theexception of vitamin E (OR = 0.5 CI = 0.3-0.9). These results do not support a protective role for the above nutrients against low-grade orequivocal SIL, which constituted the majority of diagnoses in this study.

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Documento generato il 28/01/21 alle ore 08:01:33