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Titolo:
FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS
Autore:
GALZIE Z; KINSELLA AR; SMITH JA;
Indirizzi:
UNIV LIVERPOOL,DEPT BIOCHEM,POB 147 LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV LIVERPOOL,DEPT BIOCHEM LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV LIVERPOOL,DEPT SURG LIVERPOOL L69 3BX MERSEYSIDE ENGLAND
Titolo Testata:
Biochemistry and cell biology
fascicolo: 6, volume: 75, anno: 1997,
pagine: 669 - 685
SICI:
0829-8211(1997)75:6<669:FGATR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARAN-SULFATE PROTEOGLYCAN; MAMMARY EPITHELIAL-CELLS; SUBENDOTHELIAL EXTRACELLULAR-MATRIX; PLASMINOGEN-ACTIVATOR PRODUCTION; DENSITY-LIPOPROTEIN RECEPTOR; AFFINITY BINDING-SITES; DISTINCT CORE PROTEINS; HUMAN-LUNG FIBROBLASTS; ENDOTHELIAL-CELLS; MOLECULAR-CLONING;
Keywords:
FIBROBLAST GROWTH FACTOR; FGF RECEPTOR; HEPARAN SULFATE PROTEOGLYCANS; TYROSINE KINASE RECEPTORS; FGF IN TUMOR DIAGNOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
179
Recensione:
Indirizzi per estratti:
Citazione:
Z. Galzie et al., "FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS", Biochemistry and cell biology, 75(6), 1997, pp. 669-685

Abstract

Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably. The complexity of theFGF family and the FGF-induced responses is reflected in the diversity and redundancy of the FGF receptors. In this review, a number of biochemical characteristics and biological properties of the FGF family and its receptors are described and their expression both in normal tissues and in tumours is discussed. Finally we speculate on the targetting of growth inhibition agents to tumours through FGF receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:28:00