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Titolo:
INTEGRIN AND CADHERIN SYNERGY REGULATES CONTACT INHIBITION OF MIGRATION AND MOTILE ACTIVITY
Autore:
HUTTENLOCHER A; LAKONISHOK M; KINDER M; WU S; TRUONG T; KNUDSEN KA; HORWITZ AF;
Indirizzi:
UNIV ILLINOIS,DEPT CELL & STRUCT BIOL,CHEM & LIFE SCI LAB B107,601 S GOODWIN AVE URBANA IL 61801 UNIV ILLINOIS,DEPT PEDIAT URBANA IL 61801 LANKENAU MED RES CTR WYNNEWOOD PA 19096
Titolo Testata:
The Journal of cell biology
fascicolo: 2, volume: 141, anno: 1998,
pagine: 515 - 526
SICI:
0021-9525(1998)141:2<515:IACSRC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; SIGNAL-TRANSDUCTION; EXPRESSION; FIBRONECTIN; SUBUNIT; GROWTH; DIFFERENTIATION; IDENTIFICATION; MORPHOGENESIS; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A. Huttenlocher et al., "INTEGRIN AND CADHERIN SYNERGY REGULATES CONTACT INHIBITION OF MIGRATION AND MOTILE ACTIVITY", The Journal of cell biology, 141(2), 1998, pp. 515-526

Abstract

Integrin receptors play a central role in cell migration through their roles as adhesive receptors for both other cells and extracellular matrix components. In this study, we demonstrate that integrin and cadherin receptors coordinately regulate contact-mediated inhibition of cell migration. In addition to promoting proliferation (Sastry, S., M. Lakonishok, D. Thomas, J. Muschler, and A. Horwitz. 1996. J. Cell Biol.133:169-154). ectopic expression of the alpha 5 integrin in cultures of primary quail myoblasts promotes a striking contact-mediated inhibition of cell migration. Myoblasts ectopically expressing alpha 5 integrin (alpha 5 myoblasts) move normally when not in contact, but upon contact, they show inhibition of migration and motile activity (i.e., extension and retraction of membrane protrusions). As a consequence, these cells tend to grow in aggregates and do not migrate to close a wound. This phenotype is also seen with ectopic expression of beta 1 integrin, paxillin, or activated FAK (CD2 FAK) and therefore appears to result from enhanced integrin-mediated signaling. The contact inhibition observed in the alpha 5 myoblasts is mediated by N-cadherin, whose expression is upregulated more than fivefold. Perturbation studies using low calcium conditions, antibody inhibition, and ectopic expression ofwild-type and mutant N-cadherins all implicate N-cadherin in the contact inhibition of migration. Ectopic expression of N-cadherin also produces cells that show inhibited migration upon contact; however, they do not show suppressed motile activity, suggesting tl-lat integrins and cadherins coordinately regulate motile activity. These observations have potential importance to normal and pathologic processes during embryonic development and tumor metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 05:27:34