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Titolo:
P21 IS A CRITICAL CDK2 REGULATOR ESSENTIAL FOR PROLIFERATION CONTROL IN RB-DEFICIENT CELLS
Autore:
BRUGAROLAS J; BRONSON RT; JACKS T;
Indirizzi:
MIT,CTR CANC RES,DEPT BIOL,BLDG E17-519,40 AMES ST CAMBRIDGE MA 02139 MIT,CTR CANC RES,DEPT BIOL CAMBRIDGE MA 02139 MIT,HOWARD HUGHES MED INST CAMBRIDGE MA 02139 TUFTS UNIV,DEPT PATHOL BOSTON MA 02111
Titolo Testata:
The Journal of cell biology
fascicolo: 2, volume: 141, anno: 1998,
pagine: 503 - 514
SICI:
0021-9525(1998)141:2<503:PIACCR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASES; TRANSCRIPTION FACTOR; POTENTIAL MEDIATOR; TUMOR SUPPRESSION; PHASE-TRANSITION; PROTEIN-KINASE; G1 PHASE; EXPRESSION; G(1); GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
J. Brugarolas et al., "P21 IS A CRITICAL CDK2 REGULATOR ESSENTIAL FOR PROLIFERATION CONTROL IN RB-DEFICIENT CELLS", The Journal of cell biology, 141(2), 1998, pp. 503-514

Abstract

Proliferation in mammalian cells is con trolled primarily in the G1-phase of the cell cycle through the action of the G1 cyclin-dependent kinases, CDK4 and CDK2. To explore the mechanism of cellular response to extrinsic factors, specific loss of function mutations were generated in two negative regulators of G1 progression, p21 and pRB. Individually, these mutations were shown to have significant effects in G1 regulation, and when combined, Rb and p21 mutations caused more profound defects in G1. Moreover, cells deficient for pRB and p21 were uniquely capable of anchorage-independent growth. In contrast, combined absenceof pRB and p21 function was not sufficient to overcome contact inhibition of growth nor for tumor formation in nude mice. Finally, animals with the genotype Rb+/-;p21(-/-) succumbed to tumors more rapidly thanRb+/- mice, suggesting that in certain contexts mutations in these two cell cycle regulators can cooperate in tumor development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:52:27