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Titolo:
HETEROGENEITY OF THE HIPPOCAMPUS - EFFECTS OF SUBFIELD LESIONS ON LOCOMOTION ELICITED BY DOPAMINERGIC AGONISTS
Autore:
MITTLEMAN G; BRATT AM; CHASE R;
Indirizzi:
UNIV MEMPHIS,DEPT PSYCHOL MEMPHIS TN 38152
Titolo Testata:
Behavioural brain research
fascicolo: 1, volume: 92, anno: 1998,
pagine: 31 - 45
SICI:
0166-4328(1998)92:1<31:HOTH-E>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; VENTRAL STRIATUM; IBOTENIC ACID; GRANULE CELL; KAINIC ACID; PREFRONTAL CORTEX; RAT HIPPOCAMPUS; IN-VIVO; SCHIZOPHRENIA; AMPHETAMINE;
Keywords:
HIPPOCAMPUS; FIMBRIA-FORNIX; SUBICULUM; CA3-4; ENTORHINAL CORTEX; DENTATE GYRUS; NUCLEUS ACCUMBENS; IBOTENIC ACID; KAINIC ACID; COLCHICINE; DOPAMINE; D1; D2; D-AMPHETAMINE; QUINPIROLE; SKF 38393;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
G. Mittleman et al., "HETEROGENEITY OF THE HIPPOCAMPUS - EFFECTS OF SUBFIELD LESIONS ON LOCOMOTION ELICITED BY DOPAMINERGIC AGONISTS", Behavioural brain research, 92(1), 1998, pp. 31-45

Abstract

Structural abnormalities in the hippocampal formation and overactive dopamine neurotransmission in the ventral striatum are thought to be key pathologies in schizophrenia. This experiment examined the functional contribution of different hippocampal subfields to locomotion elicited by D-amphetamine (0.32-3.2 mg/kg) and the direct agonists quinpirole (0.025-0.5 mg/kg) and SKF 38393 (2.5-15.0 mg/kg). Male rats served as unoperated controls or received one of six different lesions (hippocampal formation, fimbria-fornix, subiculum, CA3-4, entorhinal cortex or dentate gyrus (DG)). The main results indicated that extensive ibotenic acid-induced lesions of the hippocampal formation, or colchicine-induced lesions of the DG enhanced locomotion elicited by the D2 agonist quinpirole. Electrolytic lesions of the fimbria-fornix, in comparison. had much larger effects and resulted in increases in the locomotorresponse to amphetamine and quinpirole. These results extend previousdemonstrations of hippocampal modulation of the ventral striatum by showing that this modulatory influence is dependent on both the location and total extent of cell loss within the hippocampal formation. The results are discussed in relation to the causes of and neurophysiological mechanisms involved in enhanced drug-induced locomotion and in terms of their implications for mental diseases including schizophrenia. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:13:03