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Titolo:
PROCALCITONIN - A NEW MARKER FOR THE ACUT E-PHASE REACTION IN ACUTE-PANCREATITIS
Autore:
BERTSCH T; RICHTER A; HOFHEINZ H; BOHM C; HARTEL M; AUFENANGER J;
Indirizzi:
UNIV HEIDELBERG,KLINIKUM MANNHEIM,INST KLIN CHEM,THEODOR KUTZER UFER 1-3 D-68167 MANNHEIM GERMANY
Titolo Testata:
Langenbecks Archiv fur Chirurgie
fascicolo: 6, volume: 382, anno: 1997,
pagine: 367 - 372
SICI:
0023-8236(1997)382:6<367:P-ANMF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
GER
Soggetto:
SERUM PROCALCITONIN; SEPSIS; PERITONITIS; INFECTION;
Keywords:
PROCALCITONIN; CLINICAL APPLICATION; SEPSIS; ACUTE PANCREATITIS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T. Bertsch et al., "PROCALCITONIN - A NEW MARKER FOR THE ACUT E-PHASE REACTION IN ACUTE-PANCREATITIS", Langenbecks Archiv fur Chirurgie, 382(6), 1997, pp. 367-372

Abstract

Procalcitonin is a protein which is found in elevated concentrations in the blood circulation during systemic bacterial, fungal or protozoal infection. In contrast to classical acute-phase proteins like C-reactive protein or interleukin-6, it is not elevated after operative trauma. In this paper we present current opinions on the assumed inductionmechanisms of the protein by cytokines and endotoxin. Furthermore, the clinical value for early detection of systemic infections in abdominal and transplantation surgery is demonstrated by examples from the literature. Our investigation shows that eight patients with necrotizingpancreatitis had a PCT mean value of 6.9 ng/ml on the day of admission. Seven patients with edematous pancreatitis had only a PCT mean value of 0.69 ng/ml. Despite these differences in the mean values, a significant difference between the normal value and the mean value of the group with necrotizing pancreatitis or edematous pancreatitis was not observed due to the wide range of PCT levels in the group of patients with necrotizing pancreatitis. The fact that only a few of the patientshad a super infected necrosis with systemic evasion of bacterias or their toxins may be the reason for this wide range. We suggest that a discrimination between superinfected necrotizing or sterile pancreatitis and edematous pancreatitis by PCT could be possible but more extensive studies with micro. biological examination of the necrotic materialare required to recognize the subgroups and to establish the real diagnostic efficiency of PCT in clinical practice, especially in the prediction of the outcome of acute pancreatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:35:25