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Titolo:
ACUTE ESTRADIOL AND PROGESTERONE ADMINISTRATION REDUCED CARDIOVASCULAR AND CATECHOLAMINE RESPONSES TO MENTAL STRESS IN MENOPAUSAL WOMEN
Autore:
DELRIO G; VELARDO A; MENOZZI R; ZIZZO G; TAVERNARI V; VENNERI MG; MARRAMA P; PETRAGLIA F;
Indirizzi:
POLICLIN MODENA,DEPT INTERNAL MED,VIA POZZO 71 I-41100 MODENA ITALY CATTEDRA MALATTIE METAB MODENA ITALY CATTEDRA ENDOCRINOL MODENA ITALY CATTEDRA OSTETR & GINECOL MODENA ITALY
Titolo Testata:
Neuroendocrinology
fascicolo: 4, volume: 67, anno: 1998,
pagine: 269 - 274
SICI:
0028-3835(1998)67:4<269:AEAPAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; PSYCHOSOCIAL STRESS; BEHAVIORAL STRESS; ESTROGEN; SEX; 17-BETA-ESTRADIOL; PLASMA; ATHEROSCLEROSIS; PREMENOPAUSAL; INHIBITION;
Keywords:
GONADAL STEROIDS; STRESS; CATECHOLAMINES; BLOOD PRESSURE; CLINICAL NEUROENDOCRINOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
G. Delrio et al., "ACUTE ESTRADIOL AND PROGESTERONE ADMINISTRATION REDUCED CARDIOVASCULAR AND CATECHOLAMINE RESPONSES TO MENTAL STRESS IN MENOPAUSAL WOMEN", Neuroendocrinology, 67(4), 1998, pp. 269-274

Abstract

Steroid hormones are involved in the regulation of sympathoadrenal activity. Since the effect of sex steroids on the cardiovascular system and catecholamine secretion could also be exerted through an acute, nongenomic mechanism, we have studied the response to mental stress (color word test, CWT) in a group of 15 menopausal women during estrogen (100 mu g of estradiol by patch), progesterone (100 mg i.m.) or placeboadministration. Systolic blood pressure (SBP) increased during CWT inthe three sessions (F = 11.0, p < 0.001) but the area under the curveof SEP was higher during placebo (2,855 +/- 131 mm Hg.min) than during estradiol (2,585 +/- 139 mm Hg.min) and progesterone (2,553 +/- 179 mm Hg.min, p < 0.05 for both). Plasma epinephrine increased during CWTin the three sessions (F = 31.1, p < 0.001) and the plasma epinephrine response to mental stress was higher during placebo than during estradiol administration (F = 4.3, p < 0.01). The area under the curve of epinephrine was 10,342 +/- 1,348 pmol/min.l during placebo and 7,280 +/- 818 pmol/min.l during estradiol (p < 0.03). The plasma glycerol levels at the end of CWT were higher during placebo (0.26 +/- 0.04 nmol/l) than during estradiol (0.19 +/- 0.03 mmol/l) and progesterone (0.17 /- 0.04 mmol/l) administration (p < 0.05 for both). No significant differences were found in the responses of diastolic blood pressure, heart rate, norepinephrine and cortisol to mental stress during placebo and estradiol or progesterone administration. This study demonstrates that acute steroid administration is able to modify the cardiovascular and catecholamine response to mental stress in menopausal women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:33:40