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Titolo:
HELICOBACTER-PYLORI INFECTION AND INSULIN-DEPENDENT DIABETES-MELLITUS
Autore:
DELUIS DA; DELACALLE H; ROY G; DEARGILA CM; VALDEZATE S; CANTON R; BOIXEDA D;
Indirizzi:
UNIV ALCALA DE HENARES,HA RAMON & CAJAL,DEPT ENDOCRINOL MADRID 28034 SPAIN UNIV ALCALA DE HENARES,HA RAMON & CAJAL,DEPT IMMUNOL MADRID 28034 SPAIN UNIV ALCALA DE HENARES,HA RAMON & CAJAL,DEPT GASTROENTEROL MADRID 28034 SPAIN UNIV ALCALA DE HENARES,HA RAMON & CAJAL,DEPT MICROBIOL MADRID 28034 SPAIN
Titolo Testata:
Diabetes research and clinical practice
fascicolo: 2, volume: 39, anno: 1998,
pagine: 143 - 146
SICI:
0168-8227(1998)39:2<143:HIAID>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH SEROPREVALENCE; GASTRITIS;
Keywords:
HELICOBACTER PYLORI SEROPREVALENCE; DIABETES MELLITUS; PATHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Deluis et al., "HELICOBACTER-PYLORI INFECTION AND INSULIN-DEPENDENT DIABETES-MELLITUS", Diabetes research and clinical practice, 39(2), 1998, pp. 143-146

Abstract

Helicobacter pylori is associated with different diseases: duodenal ulcer, rosacea, ischaemic heart disease and gastric cancer. Given the abnormal immunological response and the high prevalence of gastrointestinal symptoms in diabetic patients, we conducted a study on H. pylori prevalence among these patients. We designed a case control study of apopulation-based cohort. Eighty insulin-dependent diabetes mellitus (IDDM) patients with an average age (24.05+/-8.3 years), and 100 control subjects (25+/-7.1 years) were selected to verify the seroprevalenceof Helicobacter pylori in these populations. One serum sample was obtained from each subject for evaluation of antibodies against Helicobacter pylori, parietal cells (APA) and pancreatic islets cells (ICA). The seroprevalence of H. pylori among IDDM patients aged less than 24 years was significantly higher than among control subjects; the corresponding rate among IDDM aged greater than 24 years was significantly lower than among control subjects. Antibodies against parietal cells (APA) and islet cells (ICA) among H. pylori positive diabetic patients were significantly higher than among H. pylori negative diabetic patients. IDDM patients were subdivided on the basis of the evolutive course of diabetes. Seroprevalence of H. pylori as well as prevalence of ICAs decreased with IDDM duration. Nevertheless, Ilo variation in the prevalence of APAs during the course of diabetes was observed. We observed an association between the seroprevalence of Helicobacter pylori and the duration of IDDM. The seroprevalence of H. pylori and ICA decreasedwith the evolutive course of diabetes mellitus among IDDM. The prevalence of ICA and APA in IDDM H. pylori positive subjects was higher than among controls. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:28:49