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Titolo:
ENHANCEMENT OF LATENT INHIBITION IN THE RAT BY THE CCK ANTAGONIST PROGLUMIDE
Autore:
GRACEY DJ; BELL R; KING DJ; TRIMBLE KM; MCDERMOTT BJ;
Indirizzi:
QUEENS UNIV BELFAST,SCH PSYCHOL,DAVID KEIR BLDG BELFAST BT7 1NN ANTRIM NORTH IRELAND QUEENS UNIV BELFAST,SCH PSYCHOL BELFAST BT7 1NN ANTRIM NORTH IRELAND QUEENS UNIV BELFAST,DEPT PHARMACOL & THERAPEUT BELFAST BT7 1NN ANTRIMNORTH IRELAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 59, anno: 1998,
pagine: 1053 - 1059
SICI:
0091-3057(1998)59:4<1053:EOLIIT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC ATTENTION DISORDER; MIDBRAIN DOPAMINE NEURONS; CENTRAL-NERVOUS-SYSTEM; CHRONIC AMPHETAMINE; NUCLEUS ACCUMBENS; CHOLECYSTOKININ-B; HALOPERIDOL; MODEL; ABOLITION; RELEASE;
Keywords:
PROGLUMIDE; HALOPERIDOL; LATENT INHIBITION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Gracey et al., "ENHANCEMENT OF LATENT INHIBITION IN THE RAT BY THE CCK ANTAGONIST PROGLUMIDE", Pharmacology, biochemistry and behavior, 59(4), 1998, pp. 1053-1059

Abstract

The behavioral paradigm of latent inhibition (LI) involves the retardation of conditioning to a stimulus when paired with reinforcement, ifpreexposure to that stimulus with no significant consequence has occurred. This phenomenon is believed to reflect a process of learning to ignore stimuli as irrelevant. Disruption in LI can be considered to bean attentional deficit observed in schizophrenia. The neuropeptide cholecystokinin (CCK), which coexists with dopamine (DA) in some brain regions, has been implicated in the pathophysiology of schizophrenia. The present study examined the effects of the nonselective CCK antagonist proglumide on LI (0.25, 0.5, and 1.0 mg/kg) using a conditioned suppression of drinking procedure in rats. For purposes of comparison theeffects of haloperidol (0.1 mg/kg) were also investigated. Administration pf 1.0 and 0.5 mg/kg, but not 0.25 mg/kg, proglumide was found toreduce suppression of drinking behavior in animals preexposed (PE) toa flashing light stimulus. These animals developed LI under conditions where preexposed control animals exhibited suppression of drinking behavior similar to that of nonpreexposed (NPE) control animals. These findings for proglumide were comparable to the effects on drinking behavior of 0.1 mg/kg haloperidol. The enhancement of LI by proglumide may be interpreted in terms of CCK-dopamine interactions. Because CCK may modulate dopamine, the results reported here for proglumide strengthen the argument for the investigation of CCK-based drugs as potential antipsychotic agents. (C) 1998 Elsevier Science Inc.

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Documento generato il 30/03/20 alle ore 19:24:26