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Titolo:
PRIOR REPEATED EXPOSURE TO A 5-HT3 RECEPTOR AGONIST DOES NOT ALTER THE ETHANOL-INDUCED CONDITIONED TASTE-AVERSION IN RATS
Autore:
BIENKOWSKI P; IWINSKA K; KOROS E; PANOCKA I; PIASECKI J; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,UL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND WARSAW ACAD MED & HOSP,DEPT EXPT & CLIN PHARMACOL PL-00527 WARSAW POLAND POLISH ACAD SCI,INST GENET & ANIM BREEDING PL-05551 MROKOW POLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 59, anno: 1998,
pagine: 975 - 980
SICI:
0091-3057(1998)59:4<975:PRETA5>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
M-CHLOROPHENYLBIGUANIDE; DRUG DISCRIMINATION; STIMULUS PROPERTIES; ANTAGONIST; SUBSTITUTION; ACTIVATION; RELEASE; CUE;
Keywords:
ETHANOL; 5-HT3 RECEPTOR; 1-(M-CHLOROPHENYL)-BIGUANIDE; CROSSFAMILIARIZATION; CONDITIONED TASTE AVERSION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski et al., "PRIOR REPEATED EXPOSURE TO A 5-HT3 RECEPTOR AGONIST DOES NOT ALTER THE ETHANOL-INDUCED CONDITIONED TASTE-AVERSION IN RATS", Pharmacology, biochemistry and behavior, 59(4), 1998, pp. 975-980

Abstract

Several reports have indicated that the brain serotonergic 5-HT3 receptors are involved in at least some central effects of ethanol in rats. However, using an operant drug discrimination procedure, we have shown that these receptors are not primarily involved in the discriminative stimulus effects of ethanol. The aim of the present study was to further elucidate the role of 5-HT3 receptors in the formation of the ethanol-cueing effects in rats. To this purpose, a crossfamiliarization conditioned taste aversion (CF-CTA) procedure was used. Four dairy injections of 1.5 g/kg ethanol (10% v/v) resulted in a significant attenuation of the subsequent ethanol-induced CTA. In contrast, four daily injections of the 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide (mCPBG; 50 mu g per rat, ICV) did not alter the subsequent ethanol-induced CTA. The 50 mu g dose of mCPBG produced a marked CTA in a controlexperiment. These results taken together with some previous findings from our laboratory suggest that the brain 5-HT3 receptors do not playany crucial role in the mediation of the discriminative stimulus effects of ethanol. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:45:47