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Titolo:
EFFECTS OF MUSCIMOL OR HOMOTAURINE ON SLEEP-WAKE STATES IN ALCOHOL-DEPENDENT RATS DURING WITHDRAWAL
Autore:
ROUHANI S; DALLAVASANTUCCI J; BAJENARU O; EMMANOUILIDIS E; TRAN G; MANICOM R; DINHXUAN AT; POENARU S;
Indirizzi:
HOP COCHIN,SERV PHYSIOL EXPLORAT FONCTIONNELLES,27 RUE FAUBOURG ST JACQUES F-75674 PARIS FRANCE UFR BIOMED,NEUROENDOCRINOL LAB PARIS FRANCE
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 59, anno: 1998,
pagine: 955 - 960
SICI:
0091-3057(1998)59:4<955:EOMOHO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MECHANISMS; ETHANOL; BRAIN;
Keywords:
MUSCIMOL; HOMOTAURINE; GABA(A) RECEPTORS; SLEEP-WAKE STATES; ALCOHOL-DEPENDENCE; WITHDRAWAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S. Rouhani et al., "EFFECTS OF MUSCIMOL OR HOMOTAURINE ON SLEEP-WAKE STATES IN ALCOHOL-DEPENDENT RATS DURING WITHDRAWAL", Pharmacology, biochemistry and behavior, 59(4), 1998, pp. 955-960

Abstract

Sleep-wake states were studied following withdrawal in 36 adult male wistar alcohol-dependent rats, after chronic administration of ethanol(10 g/kg/24 h) for 13 days. In the light phase of the withdrawal day,12 alcohol-dependent rats received muscimol (0.25 mg/kg), 12 receivedhomotaurine (140 mg/kg), and 12 received 0.9% physiological saline (10 ml/kg). The results have been compared with a control group of 36 rats that received water during the treatement phase of the experiment, and the 14th day received intraperitoneal muscimol or homotaurine. Muscimol significantly improves the alterations of sleep-wake states in alcohol-withdrawn rats, decreasing the percentage of active wakefulnessand increasing the percentage of REMS, but without any action on the latency of appearance of REMS, which remains shortened. The effects ofhomotaurine are less important on the wakefulness, but it also increases the percentage of REMS without influencing its latency of appearance. The influence of these GABA(A) agonists is not identical during the whole period of survey in the light phase, as there are important differences in the temporal sequences for each of them. We conclude thatthe stimulation of GABA(A) receptors, of which the activity is decreased during alcohol withdrawal, significantly improves the disturbancesin the sleep-wake states in the alcohol-dependent rats, in a time-related manner, and there are significant pharmacodynamic differences between muscimol and homotaurine. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:21:09