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Titolo:
SARMAZENIL-PRECIPITATED WITHDRAWAL - A RELIABLE METHOD FOR ASSESSING DEPENDENCE LIABILITY OF BENZODIAZEPINE RECEPTOR LIGANDS
Autore:
MARTIN JR; MOREAU JL; JENCK F; PIERI L;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,PRECLIN CNS RES,PRPN-D,BLDG 72-150 CH-4070 BASEL SWITZERLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 59, anno: 1998,
pagine: 939 - 944
SICI:
0091-3057(1998)59:4<939:SW-ARM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUIRREL-MONKEYS; PARTIAL AGONIST; RO 15-1788; FLUNITRAZEPAM; ANTAGONISTS; RO-15-1788; DIAZEPAM;
Keywords:
DIAZEPAM DEPENDENCE; PRECIPITATED WITHDRAWAL; SARMAZENIL; DIAZEPAM; BENZODIAZEPINE; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Martin et al., "SARMAZENIL-PRECIPITATED WITHDRAWAL - A RELIABLE METHOD FOR ASSESSING DEPENDENCE LIABILITY OF BENZODIAZEPINE RECEPTOR LIGANDS", Pharmacology, biochemistry and behavior, 59(4), 1998, pp. 939-944

Abstract

The benzodiazepine receptor partial inverse agonist sarmazenil exhibits in vivo proconvulsive, but not convulsant, effects in different paradigms in rodents. Intravenous sarmazenil challenge given at several fixed intervals following the termination of repeated treatment with a markedly sedative dose of diazepam in squirrel monkeys was effective in precipitating withdrawal signs, but had no comparable effects in vehicle-treated controls. The precipitated withdrawal reaction was not only robust, but it was consistently observed in all of the diazepam-treated monkeys. Thus, the use of sarmazenil challenge in the precipitated withdrawal paradigm provides a reliable method for assessing the development of physical dependence during repeated treatment with benzodiazepine receptor agonists. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:27:07