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Titolo:
LONG-TERM EFFECTS OF REPEATED MATERNAL SEPARATION ON 3 DIFFERENT LATENT INHIBITION PARADIGMS
Autore:
LEHMANN J; STOHR T; SCHULLER J; DOMENEY A; HEIDBREDER C; FELDON J;
Indirizzi:
ETH ZURICH,INST TOXICOL,LAB BEHAV BIOL & FUNCT TOXICOL,SCHORENSTR 16 CH-8603 SCHWERZENBACH SWITZERLAND ETH ZURICH,INST TOXICOL,LAB BEHAV BIOL & FUNCT TOXICOL CH-8603 SCHWERZENBACH SWITZERLAND F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,PRECLIN CNS RES CH-4070 BASELSWITZERLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 59, anno: 1998,
pagine: 873 - 882
SICI:
0091-3057(1998)59:4<873:LEORMS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTHER-INFANT SEPARATION; PITUITARY-ADRENAL AXIS; FEMALE RATS; ADULT-RATS; ESTROUS-CYCLE; DEPRIVATION; STRESS; AMPHETAMINE; BEHAVIOR; RESPONSES;
Keywords:
RAT; MATERNAL SEPARATION; LATENT INHIBITION; STEREOTYPY; OPEN FIELD; AMPHETAMINE; APOMORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Lehmann et al., "LONG-TERM EFFECTS OF REPEATED MATERNAL SEPARATION ON 3 DIFFERENT LATENT INHIBITION PARADIGMS", Pharmacology, biochemistry and behavior, 59(4), 1998, pp. 873-882

Abstract

In the present study we investigated the effect of repeated maternal separation on postnatal days 12, 14, 16, and 18 for 6 h/day on Wistar rats on three latent inhibition (LI) paradigms: two-way active avoidance, conditioned emotional response (CER), and conditioned taste aversion (CTA). In addition, hyperactivity induced by d-amphetamine and stereotypies induced by apomorphine were evaluated. In all three LI experiments, the control animals showed only marginal LI, whereas the maternally separated animals showed enhanced LI (only males in CTA). In two-way active avoidance within the nonpreexposed condition maternally separated animals showed improved acquisition of avoidance learning compared with the control animals. Sensitivity in response to amphetamine and apomorphine was not altered by the maternal separation procedure. Thus, maternal separation in this study, contrary to previous reports, but in line with results obtained following early handling before weaning, led to enhancement of the LI phenomenon as assessed in each of the three procedures. As our maternal separation procedure (6 h on days 12, 14, 16, and 18) led to behavioral outcomes that differed from those reported by Ellenbroek and Cools (24 h on day 10), it is suggested that maternal separation regimens that are dissimilar may lead to different and sometimes opposite behavioral effects. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:21:44