Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EARLY MATERNAL SEPARATION INCREASES NGF EXPRESSION IN THE DEVELOPING RAT HIPPOCAMPUS
Autore:
CIRULLI F; MICERA A; ALLEVA E; ALOE L;
Indirizzi:
CNR,INST NEUROBIOL,VIALE C MARX 15 I-00137 ROME ITALY CNR,INST NEUROBIOL I-00137 ROME ITALY STANFORD UNIV,SCH MED,PROGRAM NEUROSCI STANFORD CA 94305 IST SUPER SANITA,LAB FISIOPATOL ORGANO & SISTEMA,SECT BEHAV PATHOPHYSIOL I-00161 ROME ITALY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 59, anno: 1998,
pagine: 853 - 858
SICI:
0091-3057(1998)59:4<853:EMSINE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; FACTOR MESSENGER-RNA; CHOLINE-ACETYLTRANSFERASE ACTIVITY; ADRENAL HORMONES; DENTATE GYRUS; NEONATAL RATS; NEURONS; BRAIN; SCHIZOPHRENIA; HYPOTHALAMUS;
Keywords:
NGF; GENE EXPRESSION; DEVELOPMENT; MATERNAL SEPARATION; HIPPOCAMPUS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
F. Cirulli et al., "EARLY MATERNAL SEPARATION INCREASES NGF EXPRESSION IN THE DEVELOPING RAT HIPPOCAMPUS", Pharmacology, biochemistry and behavior, 59(4), 1998, pp. 853-858

Abstract

Nerve Growth Factor (NGF) is a neurotrophin involved in growth and differentiation of central cholinergic neurons. In this study a maternalseparation paradigm was used to test whether levels of NGF might be affected by brief manipulations of rat pups early during ontogeny. The expression of NGF mRNA was examined in 3-day-old rat pups following 45min maternal separation using in situ hybridization. Early maternal separation in neonatal rats resulted in increased expression of NGF mRNA in the dentate gyrus and the hilus of the hippocampus. NGF protein levels measured (by means of a sensitive ELISA assay) in the whole hippocampus the day following the separation procedure did not differ in separated vs. nonseparated pups. These data indicate that brief manipulations performed early during development can affect hippocampal NGF expression. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:24:41