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Titolo:
STRAIN DIFFERENCES IN OPEN-FIELD AND ELEVATED PLUS-MAZE BEHAVIOR OF RATS WITHOUT AND WITH PRETEST HANDLING
Autore:
SCHMITT U; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55101 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55101 MAINZ GERMANY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 59, anno: 1998,
pagine: 807 - 811
SICI:
0091-3057(1998)59:4<807:SDIOAE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERINATAL FLUMAZENIL; ANIMAL-MODELS; ANXIETY; MICE; EMOTIONALITY; DIAZEPAM; BENZODIAZEPINES; STIMULATION; AVOIDANCE; AGENTS;
Keywords:
RAT; SPRAGUE DAWLEY; PVG; OPEN FIELD; ENRICHED OPEN FIELD; ELEVATED PLUS-MAZE; HANDLING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
U. Schmitt e C. Hiemke, "STRAIN DIFFERENCES IN OPEN-FIELD AND ELEVATED PLUS-MAZE BEHAVIOR OF RATS WITHOUT AND WITH PRETEST HANDLING", Pharmacology, biochemistry and behavior, 59(4), 1998, pp. 807-811

Abstract

Behavior of two rat strains was analyzed with and without 1-week pretest handling. Male rats (150-200 g body weight) of the strains PVG/OlaHsd (PVG) and Hsd:Sprague-DawleySD (SPRD) were tested once in a standard open field and an enriched open field and twice in an elevated plus-maze. Behavioral analysis revealed significant differences between the two strains and differential effects of the pretest handling procedure. SPRD rats displayed higher levels of activity and exploratory behavior than the PVG rats, whereas PVG rats were obviously less anxious. One-week pretest handling had an ''anxiolytic'' effect and changed activity and exploration-related behavior of the animals in both strains. Activity-related parameters were mainly affected in SPRD rats and anxiety-related ones in PVG rats. The data give evidence that differencesin behavior of rats are not only determined genetically but also by preceding handling procedures. Because the two rat strains responded differentially to the pretest handling, we recommend to use a well-defined handling procedure before starting a behavioral test, especially when drug applications are included. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:21:03