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Titolo:
PROTECTION AGAINST APOPTOSIS BY MONOAMINE-OXIDASE-A INHIBITORS
Autore:
MALORNI W; GIAMMARIOLI AM; MATARRESE P; PIETRANGELI P; AGOSTINELLI E; CIACCIO A; GRASSILLI E; MONDOVI B;
Indirizzi:
IST SUPER SANITA,DEPT ULTRASTRUCT,VIALE REGINA ELENA 299 I-00161 ROMEITALY UNIV ROMA LA SAPIENZA,DEPT BIOCHEM SCI ROME ITALY UNIV ROMA LA SAPIENZA,CNR,CTR MOL BIOL ROME ITALY UNIV MODENA,DEPT GEN PATHOL MODENA ITALY
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 426, anno: 1998,
pagine: 155 - 159
SICI:
0014-5793(1998)426:1<155:PAABMI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; MITOCHONDRIAL-DNA; N-ACETYLCYSTEINE; U937 CELLS; POLYAMINES;
Keywords:
APOPTOSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; AMINE OXIDASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
W. Malorni et al., "PROTECTION AGAINST APOPTOSIS BY MONOAMINE-OXIDASE-A INHIBITORS", FEBS letters, 426(1), 1998, pp. 155-159

Abstract

Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis, This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. paragyline, clorgyline and deprenyl, on mitochondrial integrityand apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis, (C) 1998 Federation ofEuropean Biochemical Societies.

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Documento generato il 29/09/20 alle ore 23:40:42