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Titolo:
A MULTICENTER STUDY OF PLATELET RECOVERY AND UTILIZATION IN PATIENTS AFTER MYELOABLATIVE THERAPY AND HEMATOPOIETIC STEM-CELL TRANSPLANTATION
Autore:
BERNSTEIN SH; NADEMANEE AP; VOSE JM; TRICOT G; FAY JW; NEGRIN RS; DIPERSIO J; RONDON G; CHAMPLIN R; BARNETT MJ; CORNETTA K; HERZIG GP; VAUGHAN W; GEILS G; KEATING J; MESSNER H; WOLFF SN; MILLER KB; LINKER C; CAIRO M; HELLMANN S; ASHBY M; STRYKER S; NASH RA;
Indirizzi:
ROSWELL PK CANC INST,ELM & CARLTON STS BUFFALO NY 14263 EPIDEMIOL PLATELET RECOVERY STUDY GRP S SAN FRANCISCO CA 00000 GENENTECH INC S SAN FRANCISCO CA 94080
Titolo Testata:
Blood
fascicolo: 9, volume: 91, anno: 1998,
pagine: 3509 - 3517
SICI:
0006-4971(1998)91:9<3509:AMSOPR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; COLONY-STIMULATING FACTOR; TRANSFUSION; ENGRAFTMENT; DONORS; TRIAL; THROMBOCYTOPENIA; CHEMOTHERAPY; LEUKEMIA; LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Bernstein et al., "A MULTICENTER STUDY OF PLATELET RECOVERY AND UTILIZATION IN PATIENTS AFTER MYELOABLATIVE THERAPY AND HEMATOPOIETIC STEM-CELL TRANSPLANTATION", Blood, 91(9), 1998, pp. 3509-3517

Abstract

An observational study was conducted at 18 transplant centers in the United States and Canada to characterize the platelet recovery of patients receiving myeloablative therapy and stem cell transplantation andto determine the clinical variables influencing recovery, determine platelet utilization and cost, and incidence of hemorrhagic events. Thestudy included 789 evaluable patients transplanted in 1995. Clinical,laboratory, and outcome data were obtained from the medical records. Variables associated with accelerated recovery in multivariate models included (1) higher CD34 count; (2) higher platelet count at the startof myeloablative therapy; (3) graft from an HLA-identical sibling donor; and (4) prior stem cell transplant. Variables associated with delayed recovery were (1) prior radiation therapy: (2) posttransplant fever; (3) hepatic veno-occlusive disease; and (4) use of posttransplant growth factors. Disease type also influenced recovery. Recipients of peripheral blood stem cells (PBSC) had faster recovery and fewer platelet transfusion days than recipients of bone marrow (BM). The estimated average 60-day platelet transfusion cost per patient was $4,000 for autologous PBSC and $11,000 for allogeneic BM transplants. It was found that 11% of all patients had a significant hemorrhagic event during the first 60 days posttransplant, contributing to death in 2% of patients. In conclusion, clinical variables influencing platelet recovery should be considered in the design and interpretation of clinical strategies to accelerate recovery. Enhancing platelet recovery is not likely to have a significant impact on 60-day mortality but could significantly decrease health care costs and potentially improve patient quality of life. (C) 1998 by The American Society of Hematology.

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Documento generato il 08/07/20 alle ore 01:36:19