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Titolo:
CHARACTERIZATION OF CK-BETA-8 AND CK-BETA-8-1 - 2 ALTERNATIVELY SPLICED FORMS OF HUMAN BETA-CHEMOKINE, CHEMOATTRACTANTS FOR NEUTROPHILS, MONOCYTES, AND LYMPHOCYTES, AND POTENT AGONISTS AT CC-CHEMOKINE RECEPTOR-1
Autore:
YOUN BS; ZHANG SM; BROXMEYER HE; COOPER S; ANTOL K; FRASER M; KWON BS;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT IMMUNOL & MICROBIOL,635 BARNHILL DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT IMMUNOL & MICROBIOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,WALTHER ONCOL CTR INDIANAPOLIS IN 46202 ST MARYS COLL,DEPT CHEM PHYS NOTRE DAME IN 46556 UNIV NOTRE DAME,DEPT BIOL SCI S BEND IN 00000
Titolo Testata:
Blood
fascicolo: 9, volume: 91, anno: 1998,
pagine: 3118 - 3126
SICI:
0006-4971(1998)91:9<3118:COCAC->2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; FUNCTIONAL EXPRESSION; COLONY FORMATION; IDENTIFICATION; MIP-1-ALPHA; PROGENITORS; MIP-1-BETA; PROTEINS; RANTES; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Youn et al., "CHARACTERIZATION OF CK-BETA-8 AND CK-BETA-8-1 - 2 ALTERNATIVELY SPLICED FORMS OF HUMAN BETA-CHEMOKINE, CHEMOATTRACTANTS FOR NEUTROPHILS, MONOCYTES, AND LYMPHOCYTES, AND POTENT AGONISTS AT CC-CHEMOKINE RECEPTOR-1", Blood, 91(9), 1998, pp. 3118-3126

Abstract

Two new members of human beta-chemokine cDNA were isolated based on structural and functional similarities to human leukotactin-1. One of these clones was identical to the previously isolated human beta-chemokine, CK beta 8, whereas the other is a splicing variant of CK beta 8, therefore named CK beta 8-1. CK beta 8 was short in 51 nucleotides (17amino acids) compared with CK beta 8-1. The mature proteins of CK beta 8-1 and CK beta 8 consisted of 116 and 99 amino acids with calculated molecular weights of 12,500 and 10,950, respectively. Both CK beta-1and CK beta 8 were potent agonists at CCR1. These chemokines chemoattracted neutrophils, monocytes, and lymphocytes, They also significantly suppressed colony formation by human bone marrow, granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors. To our knowledge, this is the first example that an alternative splicing produces two active beta-chemokines from a single gene. (C) 1998 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:54:06