Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BEHAVIOR IN MICE WITH TARGETED DISRUPTION OF SINGLE GENES
Autore:
NELSON RJ; YOUNG KA;
Indirizzi:
JOHNS HOPKINS UNIV,DEPT PSYCHOL BALTIMORE MD 21218 JOHNS HOPKINS UNIV,DEPT NEUROSCI BALTIMORE MD 21218 JOHNS HOPKINS UNIV,DEPT POPULAT DYNAM BALTIMORE MD 21218
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 3, volume: 22, anno: 1998,
pagine: 453 - 462
SICI:
0149-7634(1998)22:3<453:BIMWTD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NEURONAL NITRIC-OXIDE; CALMODULIN KINASE-II; ESTROGEN-RECEPTOR GENE; FYN TYROSINE KINASE; MGLUR1 MUTANT MICE; DEFICIENT MICE; NULL MUTATION; AGGRESSIVE-BEHAVIOR; DOPAMINE-RECEPTOR;
Keywords:
KNOCKOUT; TARGETED GENE DELETION; LEARNING; MEMORY; LONG TERM POTENTIATION; AGGRESSION; REPRODUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
112
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Nelson e K.A. Young, "BEHAVIOR IN MICE WITH TARGETED DISRUPTION OF SINGLE GENES", Neuroscience and biobehavioral reviews, 22(3), 1998, pp. 453-462

Abstract

The use of mice with targeted deletion, or knockout, of specific genes provides a relatively new approach to establish the molecular bases of behavior. As with all ablation studies, the interpretation of behavioral data may be limited by the technique. For example, indirect effects of the missing gene may affect behavior, rather than the missing gene per se. Also, because the missing gene might affect many developmental processes throughout ontogeny and because up-regulation or compensatory mechanisms may be activated in knockouts, behavioral data from mice with targeted gene deletions should be interpreted with caution. The development of conditional knockouts, in which a specific gene canbe inactivated any time during ontogeny, should allow investigators to avoid these conceptual shortcomings associated with behavioral data from knockouts in the near future. The behavioral alterations reportedin knockout mice are reviewed here. Many dramatic changes in complex motivated behaviors including aggression, sexual, ingestive, and parental behaviors, have been reported for knockouts. There have also been many reports of alterations in sensorimotor abilities and spontaneous activity, as well as impairments in balance, coordination, and gait. Impaired learning and memory have also been reported for mice with targeted disruption of specific genes. Taken together, the use of knockouts will provide an important new tool to understand the mechanisms underlying behavior. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:31:53