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Titolo:
METABOLIC-DRUG INTERACTIONS WITH SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRI) ANTIDEPRESSANTS
Autore:
BAKER GB; FANG J; SINHA S; COUTTS RT;
Indirizzi:
UNIV ALBERTA,DEPT PSYCHIAT,NEUROCHEM RES UNIT EDMONTON AB T6G 2B7 CANADA
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 2, volume: 22, anno: 1998,
pagine: 325 - 333
SICI:
0149-7634(1998)22:2<325:MIWSSR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LIVER-MICROSOMES; SPARTEINE OXIDATION POLYMORPHISM; CYTOCHROME-P450 CYP2D LOCUS; INTERACTIONS IN-VIVO; TRICYCLIC ANTIDEPRESSANTS; PANIC DISORDER; PLASMA-LEVELS; CLINICAL PHARMACOKINETICS; DEPRESSIVE-ILLNESS; POOR METABOLIZERS;
Keywords:
ANTICONVULSANTS; ANTIDEPRESSANTS; ANTIPSYCHOTICS; ANXIOLYTICS; CYTOCHROME P450; GENETIC POLYMORPHISM; ISOZYMES; METABOLISM; SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
154
Recensione:
Indirizzi per estratti:
Citazione:
G.B. Baker et al., "METABOLIC-DRUG INTERACTIONS WITH SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRI) ANTIDEPRESSANTS", Neuroscience and biobehavioral reviews, 22(2), 1998, pp. 325-333

Abstract

The Selective serotonin reuptake inhibitor (SSRI) antidepressants have become an important component of the therapeutic armamentarium in psychiatry and have attracted a great deal of public attention. Another interesting aspect of the SSRIs is their interaction with various isozymes of the cytochrome P450 (CYP) system which are responsible for metabolism of numerous drugs. This effect on the CYP isozymes has drawn attention to the importance of metabolic drug-drug interactions when dealing with drugs used to treat psychiatric disorders. Such interactions are of great relevance since psychiatry patients are frequently treated with multiple drugs and often these drugs undergo extensive biotransformation to metabolites which contribute to therapeutic and/or adverse effects. The present review deals with various aspects of metabolism mediated by CYP isozymes, particularly as they relate to pharmacokinetic interactions between the SSRIs and other drugs which are coadministered with them. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:59:52