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Titolo:
CONTRIBUTION OF GROWTH-HORMONE DEFICIENCY TO THE GROWTH FAILURE THAT FOLLOWS BONE-MARROW TRANSPLANTATION
Autore:
BRAUNER R; ADAN L; SOUBERBIELLE JC; ESPEROU H; MICHON J; DEVERGIE A; GLUCKMAN E; ZUCKER JM;
Indirizzi:
HOP NECKER ENFANTS MALAD,149 RUE SEVRES F-75743 PARIS 15 FRANCE UNIV PARIS 05,PEDIAT ENDOCRINOL UNIT PARIS FRANCE UNIV PARIS 05,PHYSIOL LAB PARIS FRANCE HOP ST LOUIS,ASSISTANCE PUBL HOP PARIS,BONE MARROW TRANSPLANTAT UNIT PARIS FRANCE INST CURIE,PEDIAT ONCOL UNIT PARIS FRANCE
Titolo Testata:
The Journal of pediatrics
fascicolo: 5, volume: 130, anno: 1997,
pagine: 785 - 792
SICI:
0022-3476(1997)130:5<785:COGDTT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL-BODY IRRADIATION; MASS INDEX; CHILDREN; LEUKEMIA; BUSULFAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R. Brauner et al., "CONTRIBUTION OF GROWTH-HORMONE DEFICIENCY TO THE GROWTH FAILURE THAT FOLLOWS BONE-MARROW TRANSPLANTATION", The Journal of pediatrics, 130(5), 1997, pp. 785-792

Abstract

Conditioning for bone marrow transplantation (BMT) by total body irradiation frequently causes growth failure. The contribution of growth hormone (GH) deficiency to this failure was assessed in 38 patients given three types of body irradiation: group 1 (n = 18) was given 12 Gy total body irradiation as six fractions, group 2 (n = 14) 10 Gy (one dose) total body irradiation, and group 3 (n = 6) 6 Gy (one dose) thoracoabdominal irradiation, which did not involve the hypothalamic-pituitary area. At the first evaluation, 2.9 +/- 0.2 (SE) years after BMT, the values for the plasma insulin-like growth factor I (IGF-I) and its GH-dependent binding protein (IGFBP-3) were similar in groups 1 and 2 but significantly greater in group 3 (p < 0.02 for IGF-I and 0.01 for IGFBP-3). These values were similar in those patients in groups 1 and 2who had low GH peaks after stimulation (12 patients: IGF-I, 0.8 +/- 0.2 U/ml; IGFBP-3, 1.6 +/- 0.2 mg/L) and in those with normal GH peaks (20 patients: 1 +/- 0.1 U/ml and 1.8 +/- 0.1 mg/L). The decrease in height 2 years after BMT was significantly (p < 0.01) greater in group 2than in groups 1 and 3, but 5 years after BMT ii was similar in groups 1 and 2 (0.9 +/- 0.2 and 1.4 +/- 0.3 SD), significantly (p < 0.05) greater in group 2 than in group 3 (0.7 +/- 0.2 SD). The individual height changes between BMT and the last clinical evaluation before GH therapy were not correlated with the age at BMT, GH peak after stimulation, plasma IGF-I concentration, or IGFBP-3 concentration. Seven patients with GH deficiency were given GH therapy; their growth rate became normal for age (-2.1 +/- 0.9 SDS before and -0.2 +/- 0.4 SDS for the first year; not significant) without any catch-up growth. We conclude that plasma IGF-I and IGFBP-3 values are of no diagnostic value for GH deficiency after TBI. Their normal or high levels, despite low GH peaks, suggest that bone irradiation induces lesions causing resistance to IGF-I.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:03:11