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Titolo:
CORRELATION OF TGF-ALPHA AND EGF-RECEPTOR EXPRESSION WITH PROLIFERATIVE ACTIVITY IN HUMAN ASTROCYTIC GLIOMAS
Autore:
VONBOSSANYI P; SALLABA J; DIETZMANN K; WARICHKIRCHES M; KIRCHES E;
Indirizzi:
UNIV MAGDEBURG,DEPT NEUROPATHOL,LEIPZIGER STR 44 D-39120 MAGDEBURG GERMANY DIST HOSP,DEPT INTERNAL MED GARDELEGEN GERMANY
Titolo Testata:
Pathology research and practice
fascicolo: 3, volume: 194, anno: 1998,
pagine: 141 - 147
SICI:
0344-0338(1998)194:3<141:COTAEE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; GENE AMPLIFICATION; BRAIN-TUMORS; SIGNAL-TRANSDUCTION; MALIGNANT GLIOMAS; NERVOUS-SYSTEM; MESSENGER-RNA; NEU ONCOGENE; HEREGULIN; PROTEIN;
Keywords:
GLIOMA; TRANSFORMING GROWTH FACTOR ALPHA; EPIDERMAL GROWTH FACTOR RECEPTOR; C-ERBB-2 ONCOPROTEIN; KI-67;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
P. Vonbossanyi et al., "CORRELATION OF TGF-ALPHA AND EGF-RECEPTOR EXPRESSION WITH PROLIFERATIVE ACTIVITY IN HUMAN ASTROCYTIC GLIOMAS", Pathology research and practice, 194(3), 1998, pp. 141-147

Abstract

Fifty-nine paraffin-embedded astrocytic gliomas (four WHO grade 1, 21WHO grade 2, 17 WHO grade 3 and 17 glioblastomas, WHO grade 4) were immunohistochemically investigated for expression of transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGF-R) and oncoprotein c-erbR-2 by semiquantitative assessment. Proliferative activity was simultaneously analyzed by using the antibody Ki-67 (MIB-1). Immunostaining in neoplastic cells was quantified by image analysis. Concerning the antibodies used, the percentage of immunoreactive cells increased with histologic malignancy. There was no expression of EGF-R and c-erbB-2 in the majority of low-grade astrocytomas. However, small focal expressions of TGF-alpha and EGF-R were observed in several low-grade astrocytomas (11/25), suggesting an early stimulation of malignant transformation. With regard to percentage, a strong positive correlation between TGF alpha and EGF-R-stained cells was found, indicating an autocrine stimulation of the mitogenic pathway of the TGF-alpha/EGF-R system. Likewise, indices of EGF-R and c-erbB-2 positive cells correlated significantly. Less significant correlations were also sfen between EGF-R, c-erbB-2 frequencies and the Ki-67 labeling index. However, there was no correlation between TGF-alpha and Ki-67 indices. The results suggest that TGF-alpha expression is not directly relatedto the proliferative potential as judged by the Ki-67 labeling index. Furthermore, besides EGF-R and c-erbB-2, other growth factors and their receptors or mutant EGF-R might participate in the proliferative activity of gliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:41:35